BMAA neurotoxicity in Drosophila

Xianchong Zhou, Wilfredo Escala, Spyridon Papapetropoulos, Walter G. Bradley, R. Grace Zhai

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalAmyotrophic Lateral Sclerosis
Volume10
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 1 2009

Keywords

  • ALS
  • Drosophila
  • Neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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