BMAA neurotoxicity in Drosophila

Xianchong Zhou; Wilfredo Escala; Spyridon Papapetropoulos; Walter G. Bradley; R. Grace Zhai

doi:10.3109/17482960903273445

BMAA neurotoxicity in Drosophila

Xianchong Zhou, Wilfredo Escala, Spyridon Papapetropoulos, Walter G. Bradley, R. Grace Zhai

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

Original language	English (US)
Pages (from-to)	61-66
Number of pages	6
Journal	Amyotrophic Lateral Sclerosis
Volume	10
Issue number	SUPPL. 2
DOIs	https://doi.org/10.3109/17482960903273445
State	Published - 2009

Keywords

ALS
Drosophila
Neurodegeneration

ASJC Scopus subject areas

Clinical Neurology
Neurology

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title = "BMAA neurotoxicity in Drosophila",

abstract = "We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.",

keywords = "ALS, Drosophila, Neurodegeneration",

author = "Xianchong Zhou and Wilfredo Escala and Spyridon Papapetropoulos and Bradley, {Walter G.} and Zhai, {R. Grace}",

note = "Funding Information: We express thanks for the generous support and technical help provided by Paul Cox, Sandra Banack, and Holly Johnson.We also thank Brant Watson for critical reading of the manuscript. This work was supported by funding to RGZ from the Neuroscience Center at the University of Miami, Miller School of Medicine, and to SP from the MDA foundation.",

year = "2009",

doi = "10.3109/17482960903273445",

language = "English (US)",

volume = "10",

pages = "61--66",

journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",

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T1 - BMAA neurotoxicity in Drosophila

AU - Zhou, Xianchong

AU - Escala, Wilfredo

AU - Papapetropoulos, Spyridon

AU - Bradley, Walter G.

AU - Zhai, R. Grace

N1 - Funding Information: We express thanks for the generous support and technical help provided by Paul Cox, Sandra Banack, and Holly Johnson.We also thank Brant Watson for critical reading of the manuscript. This work was supported by funding to RGZ from the Neuroscience Center at the University of Miami, Miller School of Medicine, and to SP from the MDA foundation.

PY - 2009

Y1 - 2009

N2 - We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

AB - We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

KW - ALS

KW - Drosophila

KW - Neurodegeneration

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U2 - 10.3109/17482960903273445

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AN - SCOPUS:74549115178

VL - 10

SP - 61

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JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

SN - 2167-8421

IS - SUPPL. 2

ER -

BMAA neurotoxicity in Drosophila

Abstract

Keywords

ASJC Scopus subject areas

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