BMAA neurotoxicity in Drosophila

Xianchong Zhou, Wilfredo Escala, Spyridon Papapetropoulos, Walter G Bradley, Rong G Zhai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalAmyotrophic Lateral Sclerosis
Volume10
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 1 2009

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Diptera
Drosophila
Tissue Extracts
Poisons
Drosophila melanogaster
Fruit
High Pressure Liquid Chromatography
Proteins
beta-N-methylamino-L-alanine

Keywords

  • ALS
  • Drosophila
  • Neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

BMAA neurotoxicity in Drosophila. / Zhou, Xianchong; Escala, Wilfredo; Papapetropoulos, Spyridon; Bradley, Walter G; Zhai, Rong G.

In: Amyotrophic Lateral Sclerosis, Vol. 10, No. SUPPL. 2, 01.12.2009, p. 61-66.

Research output: Contribution to journalArticle

Zhou, X, Escala, W, Papapetropoulos, S, Bradley, WG & Zhai, RG 2009, 'BMAA neurotoxicity in Drosophila', Amyotrophic Lateral Sclerosis, vol. 10, no. SUPPL. 2, pp. 61-66. https://doi.org/10.3109/17482960903273445
Zhou, Xianchong ; Escala, Wilfredo ; Papapetropoulos, Spyridon ; Bradley, Walter G ; Zhai, Rong G. / BMAA neurotoxicity in Drosophila. In: Amyotrophic Lateral Sclerosis. 2009 ; Vol. 10, No. SUPPL. 2. pp. 61-66.
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