Abstract
We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.
Original language | English (US) |
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Pages (from-to) | 61-66 |
Number of pages | 6 |
Journal | Amyotrophic Lateral Sclerosis |
Volume | 10 |
Issue number | SUPPL. 2 |
DOIs | |
State | Published - Dec 1 2009 |
Keywords
- ALS
- Drosophila
- Neurodegeneration
ASJC Scopus subject areas
- Clinical Neurology
- Neurology