BMAA neurotoxicity in Drosophila

Xianchong Zhou; Wilfredo Escala; Spyridon Papapetropoulos; Walter G. Bradley; R. Grace Zhai

doi:10.3109/17482960903273445

BMAA neurotoxicity in Drosophila

Xianchong Zhou, Wilfredo Escala, Spyridon Papapetropoulos, Walter G. Bradley, R. Grace Zhai

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

Original language	English (US)
Pages (from-to)	61-66
Number of pages	6
Journal	Amyotrophic Lateral Sclerosis
Volume	10
Issue number	SUPPL. 2
DOIs	https://doi.org/10.3109/17482960903273445
State	Published - Dec 1 2009

Keywords

ALS
Drosophila
Neurodegeneration

ASJC Scopus subject areas

Clinical Neurology
Neurology

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abstract = "We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.",

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AU - Escala, Wilfredo

AU - Papapetropoulos, Spyridon

AU - Bradley, Walter G.

AU - Zhai, R. Grace

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KW - Drosophila

KW - Neurodegeneration

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