Abstract
Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Design: Retrospective, noncomparative case series. Participants: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016. Methods: Chart review of patients identified from a database search of the Florida Lions Ocular Pathology Laboratory records. Pathologic diagnoses were confirmed by 2 pathologists (S.R.D. and G.E.). All specimens were bleached and, tissue permitting, stained using SOX10 (MilliporeSigma, Darmstadt, Germany) and CD68 (Leica Biosystems, Nussloch, Germany). Main Outcome Measures: Clinical characteristics, pathologic features, and clinical course. Results: Mean age of the population was 55±15 years; 71.4% (n = 15) were white and 57.1% (n = 12) were men. One patient had 3 lesions, for a total of 23 lesions examined. Clinically, 13 lesions were on the bulbar conjunctiva, 3 were on the tarsal conjunctiva, 3 were in the fornix, 2 were caruncular, 1 was episcleral, and 1 was at the limbus. Before excision, 8 patients were thought to have primary acquired melanosis, 4 with concern for primary conjunctival melanoma, and 1 thought to have metastatic disease from a plantar melanoma. Five lesions were thought to be benign, and in 8 patients, the lesions were identified incidentally after other ocular surgeries, with no diagnosis of the lesions before excision. Pathologic features were consistent with simple blue nevi in 21 lesions and cellular blue nevus in 2 lesions. No malignant transformations were noted in any patient over the mean 20.2-month follow-up period (range, 2 weeks–103 months). Conclusions: Blue nevus is a rare deeply pigmented congenital melanocytic lesion with a benign clinical course that can appear clinically similar to primary acquired melanosis or melanoma.
| Original language | English (US) |
|---|---|
| Journal | Ophthalmology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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ASJC Scopus subject areas
- Ophthalmology
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Blue Nevi of the Ocular Surface : Clinical Characteristics, Pathologic Features, and Clinical Course. / Sayed-Ahmed, Ibrahim; Murillo, Juan Carlos; Monsalve, Pedro; Ulloa, Jan Paul; Fernandez, Maria P.; Wong, James; Elgart, George; Galor, Anat; Dubovy, Sander; Karp, Carol.
In: Ophthalmology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blue Nevi of the Ocular Surface
T2 - Clinical Characteristics, Pathologic Features, and Clinical Course
AU - Sayed-Ahmed, Ibrahim
AU - Murillo, Juan Carlos
AU - Monsalve, Pedro
AU - Ulloa, Jan Paul
AU - Fernandez, Maria P.
AU - Wong, James
AU - Elgart, George
AU - Galor, Anat
AU - Dubovy, Sander
AU - Karp, Carol
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Design: Retrospective, noncomparative case series. Participants: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016. Methods: Chart review of patients identified from a database search of the Florida Lions Ocular Pathology Laboratory records. Pathologic diagnoses were confirmed by 2 pathologists (S.R.D. and G.E.). All specimens were bleached and, tissue permitting, stained using SOX10 (MilliporeSigma, Darmstadt, Germany) and CD68 (Leica Biosystems, Nussloch, Germany). Main Outcome Measures: Clinical characteristics, pathologic features, and clinical course. Results: Mean age of the population was 55±15 years; 71.4% (n = 15) were white and 57.1% (n = 12) were men. One patient had 3 lesions, for a total of 23 lesions examined. Clinically, 13 lesions were on the bulbar conjunctiva, 3 were on the tarsal conjunctiva, 3 were in the fornix, 2 were caruncular, 1 was episcleral, and 1 was at the limbus. Before excision, 8 patients were thought to have primary acquired melanosis, 4 with concern for primary conjunctival melanoma, and 1 thought to have metastatic disease from a plantar melanoma. Five lesions were thought to be benign, and in 8 patients, the lesions were identified incidentally after other ocular surgeries, with no diagnosis of the lesions before excision. Pathologic features were consistent with simple blue nevi in 21 lesions and cellular blue nevus in 2 lesions. No malignant transformations were noted in any patient over the mean 20.2-month follow-up period (range, 2 weeks–103 months). Conclusions: Blue nevus is a rare deeply pigmented congenital melanocytic lesion with a benign clinical course that can appear clinically similar to primary acquired melanosis or melanoma.
AB - Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Design: Retrospective, noncomparative case series. Participants: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016. Methods: Chart review of patients identified from a database search of the Florida Lions Ocular Pathology Laboratory records. Pathologic diagnoses were confirmed by 2 pathologists (S.R.D. and G.E.). All specimens were bleached and, tissue permitting, stained using SOX10 (MilliporeSigma, Darmstadt, Germany) and CD68 (Leica Biosystems, Nussloch, Germany). Main Outcome Measures: Clinical characteristics, pathologic features, and clinical course. Results: Mean age of the population was 55±15 years; 71.4% (n = 15) were white and 57.1% (n = 12) were men. One patient had 3 lesions, for a total of 23 lesions examined. Clinically, 13 lesions were on the bulbar conjunctiva, 3 were on the tarsal conjunctiva, 3 were in the fornix, 2 were caruncular, 1 was episcleral, and 1 was at the limbus. Before excision, 8 patients were thought to have primary acquired melanosis, 4 with concern for primary conjunctival melanoma, and 1 thought to have metastatic disease from a plantar melanoma. Five lesions were thought to be benign, and in 8 patients, the lesions were identified incidentally after other ocular surgeries, with no diagnosis of the lesions before excision. Pathologic features were consistent with simple blue nevi in 21 lesions and cellular blue nevus in 2 lesions. No malignant transformations were noted in any patient over the mean 20.2-month follow-up period (range, 2 weeks–103 months). Conclusions: Blue nevus is a rare deeply pigmented congenital melanocytic lesion with a benign clinical course that can appear clinically similar to primary acquired melanosis or melanoma.
UR - http://www.scopus.com/inward/record.url?scp=85046072301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046072301&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2018.02.006
DO - 10.1016/j.ophtha.2018.02.006
M3 - Article
C2 - 29551421
AN - SCOPUS:85046072301
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
ER -