Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus

The Atherosclerosis Risk in Communities (ARIC) Study

Leonardo Tamariz, J. Hunter Young, James S. Pankow, Hsin Chieh Yeh, Maria Ines Schmidt, Brad Astor, Frederick L. Brancati

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Several lines of evidence support the notion that elevated blood viscosity may predispose to insulin resistance and type 2 diabetes mellitus by limiting delivery of glucose, insulin, and oxygen to metabolically active tissues. To test this hypothesis, the authors analyzed longitudinal data on 12,881 initially nondiabetic adults, aged 45-64 years, who were participants in the Atherosclerosis Risk in Communities (ARIC) Study (1987-1998). Whole blood viscosity was estimated by using a validated formula based on hematocrit and total plasma proteins at baseline. At baseline, estimated blood viscosity was independently associated with several features of the metabolic syndrome. In models adjusted simultaneously for known predictors of diabetes, estimated whole blood viscosity and hematocrit predicted incident type 2 diabetes mellitus in a graded fashion (Ptrend (linear) < 0.001): Compared with their counterparts in the lowest quartiles, adults in the highest quartile of blood viscosity (hazard ratio = 1.68, 95% confidence interval: 1.53, 1.84) and hematocrit (hazard ratio = 1.63, 95% confidence interval: 1.49, 1.79) were over 60% more likely to develop diabetes. Therefore, elevated blood viscosity and hematocrit deserve attention as emerging risk factors for insulin resistance and type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)1153-1160
Number of pages8
JournalAmerican Journal of Epidemiology
Volume168
Issue number10
DOIs
StatePublished - Nov 1 2008

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Blood Viscosity
Hematocrit
Type 2 Diabetes Mellitus
Atherosclerosis
Insulin Resistance
Confidence Intervals
Blood Proteins
Insulin
Oxygen
Glucose

Keywords

  • Blood viscosity
  • Diabetes mellitus, type 2
  • Hematocrit
  • Insulin resistance
  • Metabolic syndrome X
  • Oxidative phosphorylation

ASJC Scopus subject areas

  • Epidemiology

Cite this

Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus : The Atherosclerosis Risk in Communities (ARIC) Study. / Tamariz, Leonardo; Young, J. Hunter; Pankow, James S.; Yeh, Hsin Chieh; Schmidt, Maria Ines; Astor, Brad; Brancati, Frederick L.

In: American Journal of Epidemiology, Vol. 168, No. 10, 01.11.2008, p. 1153-1160.

Research output: Contribution to journalArticle

Tamariz, Leonardo ; Young, J. Hunter ; Pankow, James S. ; Yeh, Hsin Chieh ; Schmidt, Maria Ines ; Astor, Brad ; Brancati, Frederick L. / Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus : The Atherosclerosis Risk in Communities (ARIC) Study. In: American Journal of Epidemiology. 2008 ; Vol. 168, No. 10. pp. 1153-1160.
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