Blood transfusions, increased rates of surgical NEC, and lower survival: A propensity score-matched analysis

Arash J. Sayari, Jun Tashiro, Juan E. Sola, Eduardo A. Perez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Purpose We sought to investigate the association between blood transfusions (BT), rates of necrotizing enterocolitis requiring surgical intervention (SNEC), and survival. Methods Blood transfusions in premature infants were identified in the Kids' Inpatient Database (2003-2009). Propensity score-matched analysis compared SNEC outcomes in BT vs. non-BT groups. Multivariate analyses were performed to determine independent predictors of outcome. Results Overall, 663 740 cases were identified and 4.9% received BT. Surgical necrotizing enterocolitis occurred in 493 cases in the BT group, while SNEC occurred in 1049 cases in the non-BT group. Propensity score analysis of 20 991 BT and 20 988 non-BT cases demonstrated higher SNEC rates with BT (odds ratio [OR], 1.21) vs non-BT. Surgical necrotizing enterocolitis with BT had lower survival rates (58%) vs non-BT (67%). Surgical necrotizing enterocolitis with BT had lower length of stay and total charges vs non-BT. On multivariate analyses, SNEC mortality with BT increased for lower gestational age, males (OR, 45.7), African Americans (OR, 64.4), and infants with cardiac anomalies (OR, 50.8) or bronchopulmonary dysplasia (OR, 177). Non-BT SNEC demonstrated higher mortality with lower gestational age and infants with bronchopulmonary dysplasia (OR, 6.56) or sepsis (OR, 3.66). Conclusion On propensity score-matched analysis, SNEC occurs at higher rates after BT and is associated with lower survival and lower resource utilization vs SNEC without BT.

Original languageEnglish (US)
Pages (from-to)927-931
Number of pages5
JournalJournal of Pediatric Surgery
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Blood transfusion
  • Necrotizing enterocolitis
  • Neonatal prematurity

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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