Blood pressure, insulin, and glycemia in nondiabetic subjects

Arthur M. Fournier, Maria T. Gadia, Denise B. Kubrusly, Jay S. Skyler, Jay M. Sosenko

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

The relation of blood pressure to fasting (basal) insulin and glycosylated hemoglobin (hemoglobin A1) was examined in 248 nondiabetic subjects (137 women and 111 men). None of the subjects was taking antihypertensive medication. There were statistically significant associations of systolic and diastolic blood pressure with insulin levels (r = 0.24, p <0.01; r = 0.30, p <0.01) and hemoglobin A1 levels (r = 0.28, p <0.001; r = 0.22, p <0.05) in women. These blood pressure indexes were also related to insulin levels in men (r = 0.23, p <0.05; r = 0.02, p <0.05). In a multiple regression analysis, the association between blood pressure and insulin level was diminished with an allowance for adiposity; however, it remained statistically significant. These data indicate that blood pressure is related to insulin levels in nondiabetic subjects and suggest that insulin may be a physiologic determinant of blood pressure.

Original languageEnglish (US)
Pages (from-to)861-864
Number of pages4
JournalThe American journal of medicine
Volume80
Issue number5
DOIs
StatePublished - May 1986

ASJC Scopus subject areas

  • Medicine(all)

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