Blood flow and ischemia within traumatic cerebral contusions

Gorm Von Oettingen, Bo Bergholt, Carsten Gyldensted, Jens Astrup, Ross Bullock, Martin C. Holland, Daniel F. Kelly, Tom Glenn, J. Paul Muizelaar

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

OBJECTIVE: To provide evidence of irreversible ischemia in cerebral contusions among patients with severe traumatic brain injuries and to clarify the potential viability of tissue in the pericontusional zone, quantitative regional cerebral blood flow (rCBF) measurements obtained with the xenon-enhanced computed tomographic method were correlated with the areas of contusions, by using image fusion. METHODS: rCBF measurements obtained during the acute phase (mean, 2 d after injury; range, 0-10 d) were statistically correlated with the extent of tissue necrosis identified as focal atrophy on late follow-up computed tomographic scans (mean time after the xenon-enhanced computed tomographic cerebral blood flow investigation, 265 d; range, 30-1047 d). RESULTS: Seventeen patients exhibited 26 traumatic contusions. All contusions progressed to late focal atrophic areas on the follow-up computed tomographic scans. The rCBF values within the traumatic contusions ranged from 0.5 to 22.0 ml/100 g/min, with a mean of 5.9 ± 5.9 ml/100 g/min. The contusions exhibited a specific rCBF profile, presenting as a core of severe lethal ischemia surrounded by variable but gradually increasing perfusion with increasing distance from the ischemic core. CONCLUSION: The ischemic profile of the contusions, with a pericontusional zone of low RCBF, presents the potential risk of secondary ischemic insults, similar to the risk in the ischemic penumbral zones surrounding areas of acute ischemic stroke.

Original languageEnglish
Pages (from-to)781-790
Number of pages10
JournalNeurosurgery
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2002
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Contusions
Ischemia
Regional Blood Flow
Xenon
Tissue Survival
Atrophy
Brain Contusion
Necrosis
Perfusion
Stroke
Wounds and Injuries

Keywords

  • Contusion
  • Head injury
  • Ischemia
  • Regional cerebral blood flow
  • Xenon-enhanced computed tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Von Oettingen, G., Bergholt, B., Gyldensted, C., Astrup, J., Bullock, R., Holland, M. C., ... Muizelaar, J. P. (2002). Blood flow and ischemia within traumatic cerebral contusions. Neurosurgery, 50(4), 781-790. https://doi.org/10.1097/00006123-200204000-00019

Blood flow and ischemia within traumatic cerebral contusions. / Von Oettingen, Gorm; Bergholt, Bo; Gyldensted, Carsten; Astrup, Jens; Bullock, Ross; Holland, Martin C.; Kelly, Daniel F.; Glenn, Tom; Muizelaar, J. Paul.

In: Neurosurgery, Vol. 50, No. 4, 01.04.2002, p. 781-790.

Research output: Contribution to journalArticle

Von Oettingen, G, Bergholt, B, Gyldensted, C, Astrup, J, Bullock, R, Holland, MC, Kelly, DF, Glenn, T & Muizelaar, JP 2002, 'Blood flow and ischemia within traumatic cerebral contusions', Neurosurgery, vol. 50, no. 4, pp. 781-790. https://doi.org/10.1097/00006123-200204000-00019
Von Oettingen G, Bergholt B, Gyldensted C, Astrup J, Bullock R, Holland MC et al. Blood flow and ischemia within traumatic cerebral contusions. Neurosurgery. 2002 Apr 1;50(4):781-790. https://doi.org/10.1097/00006123-200204000-00019
Von Oettingen, Gorm ; Bergholt, Bo ; Gyldensted, Carsten ; Astrup, Jens ; Bullock, Ross ; Holland, Martin C. ; Kelly, Daniel F. ; Glenn, Tom ; Muizelaar, J. Paul. / Blood flow and ischemia within traumatic cerebral contusions. In: Neurosurgery. 2002 ; Vol. 50, No. 4. pp. 781-790.
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