Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns. Study design We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD. Results The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD. Conclusions Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.

Original languageEnglish (US)
Pages (from-to)45-51.e5
JournalJournal of Pediatrics
Volume174
DOIs
StatePublished - Jul 1 2016

Fingerprint

Extremely Low Birth Weight Infant
Bronchopulmonary Dysplasia
Cytokines
Lung Diseases
Extremely Premature Infants
Oxygen
Macrophage Inflammatory Proteins
Interleukin-18
Brain-Derived Neurotrophic Factor
Matrix Metalloproteinase 9
Granulocyte-Macrophage Colony-Stimulating Factor
Protein C
Interleukin-8
Interleukin-10
C-Reactive Protein
Interleukin-6

Keywords

  • chronic lung disease
  • inflammatory markers
  • premature infant
  • respiratory distress syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2016). Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants. Journal of Pediatrics, 174, 45-51.e5. https://doi.org/10.1016/j.jpeds.2016.03.058

Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

In: Journal of Pediatrics, Vol. 174, 01.07.2016, p. 45-51.e5.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network 2016, 'Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants', Journal of Pediatrics, vol. 174, pp. 45-51.e5. https://doi.org/10.1016/j.jpeds.2016.03.058
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants. Journal of Pediatrics. 2016 Jul 1;174:45-51.e5. https://doi.org/10.1016/j.jpeds.2016.03.058
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. / Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants. In: Journal of Pediatrics. 2016 ; Vol. 174. pp. 45-51.e5.
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abstract = "Objective To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns. Study design We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD. Results The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD. Conclusions Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.",
keywords = "chronic lung disease, inflammatory markers, premature infant, respiratory distress syndrome",
author = "{Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network} and D'Angio, {Carl T.} and Namasivayam Ambalavanan and Carlo, {Waldemar A.} and McDonald, {Scott A.} and Kristin Skogstrand and Hougaard, {David M.} and Seetha Shankaran and Goldberg, {Ronald N.} and Ehrenkranz, {Richard A.} and Tyson, {Jon E.} and Stoll, {Barbara J.} and Abhik Das and Higgins, {Rosemary D.} and Jobe, {Alan H.} and Laptook, {Abbot R.} and William Oh and Rubin, {Lewis P.} and Hensman, {Angelita M.} and Fanaroff, {Avroy A.} and Walsh, {Michele C.} and Newman, {Nancy S.} and Siner, {Bonnie S.} and Donovan, {Edward F.} and Vivek Narendran and Barbara Alexander and Cathy Grisby and Jody Hessling and Mersmann, {Marcia Worley} and Mincey, {Holly L.} and Cotten, {C. Michael} and Auten, {Kathy J.} and Hale, {Ellen C.} and Wright, {Linda L.} and Yaffe, {Sumner J.} and McClure, {Elizabeth M.} and Poindexter, {Brenda B.} and Lemons, {James A.} and Appel, {Diana D.} and Herron, {Dianne E.} and Wilson, {Leslie D.} and Poole, {W. Kenneth} and Hastings, {Betty K.} and Zaterka-Baxter, {Kristin M.} and {O'Donnell Auman}, Jeanette and Schaefer, {Scott E.} and Stevenson, {David K.} and {Van Meurs}, {Krisa P.} and Ball, {M. Bethany} and Bauer, {Charles R} and Ruth Everett-Thomas",
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T1 - Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

AU - D'Angio, Carl T.

AU - Ambalavanan, Namasivayam

AU - Carlo, Waldemar A.

AU - McDonald, Scott A.

AU - Skogstrand, Kristin

AU - Hougaard, David M.

AU - Shankaran, Seetha

AU - Goldberg, Ronald N.

AU - Ehrenkranz, Richard A.

AU - Tyson, Jon E.

AU - Stoll, Barbara J.

AU - Das, Abhik

AU - Higgins, Rosemary D.

AU - Jobe, Alan H.

AU - Laptook, Abbot R.

AU - Oh, William

AU - Rubin, Lewis P.

AU - Hensman, Angelita M.

AU - Fanaroff, Avroy A.

AU - Walsh, Michele C.

AU - Newman, Nancy S.

AU - Siner, Bonnie S.

AU - Donovan, Edward F.

AU - Narendran, Vivek

AU - Alexander, Barbara

AU - Grisby, Cathy

AU - Hessling, Jody

AU - Mersmann, Marcia Worley

AU - Mincey, Holly L.

AU - Cotten, C. Michael

AU - Auten, Kathy J.

AU - Hale, Ellen C.

AU - Wright, Linda L.

AU - Yaffe, Sumner J.

AU - McClure, Elizabeth M.

AU - Poindexter, Brenda B.

AU - Lemons, James A.

AU - Appel, Diana D.

AU - Herron, Dianne E.

AU - Wilson, Leslie D.

AU - Poole, W. Kenneth

AU - Hastings, Betty K.

AU - Zaterka-Baxter, Kristin M.

AU - O'Donnell Auman, Jeanette

AU - Schaefer, Scott E.

AU - Stevenson, David K.

AU - Van Meurs, Krisa P.

AU - Ball, M. Bethany

AU - Bauer, Charles R

AU - Everett-Thomas, Ruth

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Objective To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns. Study design We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD. Results The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD. Conclusions Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.

AB - Objective To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns. Study design We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD. Results The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD. Conclusions Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.

KW - chronic lung disease

KW - inflammatory markers

KW - premature infant

KW - respiratory distress syndrome

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