Studies of blood coagulation and fibrinolytic systems were performed in 15 Ugandan Africans with cirrhosis, 29 with hepatocellular carcinoma (14 with and 15 without concomitant cirrhosis) and 20 normal controls. Patients with cirrhosis had decreases in plasma fibrinogen, platelet count and factors of the prothrombin complex and shortening of the euglobulin lysis time. Most patients with hepatocellular carcinoma and no cirrhosis had increased plasma fibrinogen, normal or high platelet counts and normal euglobulin lysis time. In patients with liver cancer and concomitant cirrhosis, mean values for plasma fibrinogen, platelet count and euglobulin lysis time were midway between those of patients with cirrhosis and those with hepatocellular carcinoma. Prolonged thrombin times in several hepatocellular carcinoma patients in the present series, in the absence of fibrinogenopenia, circulating heparin like anticoagulants or increases in fibrinogen degradation products, suggest the possibility that dysfibrinogenaemia may be more common in hepatocellular carcinoma than previously realised.
|Original language||English (US)|
|Number of pages||13|
|Journal||East African Medical Journal|
|State||Published - Dec 1 1974|
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