Blocking the common γ-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival

Xian Chang Li, Azine Ima, Yongsheng Li, Xin Xiao Zheng, Thomas Malek, Terry B. Strom

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The common γc-chain is an essential signaling component shared by all known T cell growth factor (TCGF) receptors (i.e., IL-2, IL-4, IL-7, IL-9, and IL-15). In the present study, we have studied the effect of γc-chain blockade on T cell activation and allograft rejection. Treatment of B6AF1 (H-2(b/d.k)) recipient mice with anti-γc mAbs induced long-term survival of DBA/2 (H-2(d)) islet allografts (>150 days, n = 8), whereas control Ab- treated mice rejected the islet allografts within 17 days (n = 6). The state of engraftment induced by the anti-γc mAbs was remarkably stable, as recipient mice bearing the primary islet allografts accepted a second DBA/2 islet allograft without further immunosuppression and systemic administration of high doses of IL-2Ig fusion protein failed to provoke rejection. Blocking the γc-chain inhibited T cell proliferation and induced T cell apoptosis by repressing expression of Bcl-2. Our data suggest that one means of inducing T cell apoptosis and stable allograft survival can be achieved via γc-chain blockade.

Original languageEnglish
Pages (from-to)1193-1199
Number of pages7
JournalJournal of Immunology
Volume164
Issue number3
StatePublished - Feb 1 2000

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Allografts
Apoptosis
T-Lymphocytes
Interleukin-9
Interleukin-15
Interleukin-7
Interleukin-2 Receptors
Interleukin-4
Immunosuppression
Interleukin-2
Mouse Il27ra protein
Cell Proliferation
Proteins

ASJC Scopus subject areas

  • Immunology

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Blocking the common γ-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. / Li, Xian Chang; Ima, Azine; Li, Yongsheng; Zheng, Xin Xiao; Malek, Thomas; Strom, Terry B.

In: Journal of Immunology, Vol. 164, No. 3, 01.02.2000, p. 1193-1199.

Research output: Contribution to journalArticle

Li, Xian Chang ; Ima, Azine ; Li, Yongsheng ; Zheng, Xin Xiao ; Malek, Thomas ; Strom, Terry B. / Blocking the common γ-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. In: Journal of Immunology. 2000 ; Vol. 164, No. 3. pp. 1193-1199.
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