Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I

N. Sossi, Douglas Anderson

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOP-induced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalArchives of Ophthalmology
Volume101
Issue number1
StatePublished - Jan 1 1983

Fingerprint

Angiotensin I
Axonal Transport
Optic Nerve
Intraocular Pressure
Hypertension
Optic Disk
Axons
Cats
Ischemia

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I. / Sossi, N.; Anderson, Douglas.

In: Archives of Ophthalmology, Vol. 101, No. 1, 01.01.1983, p. 94-97.

Research output: Contribution to journalArticle

@article{2a0ac1232cb449e882ce896a4b269af2,
title = "Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I",
abstract = "Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOP-induced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.",
author = "N. Sossi and Douglas Anderson",
year = "1983",
month = "1",
day = "1",
language = "English",
volume = "101",
pages = "94--97",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "1",

}

TY - JOUR

T1 - Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I

AU - Sossi, N.

AU - Anderson, Douglas

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOP-induced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.

AB - Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOP-induced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.

UR - http://www.scopus.com/inward/record.url?scp=0020656514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020656514&partnerID=8YFLogxK

M3 - Article

C2 - 6185108

AN - SCOPUS:0020656514

VL - 101

SP - 94

EP - 97

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 1

ER -