Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure: Effect of arterial hypertension induced by angiotensin I

Nunzio Sossi, Douglas R. Anderson

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOP-induced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalArchives of ophthalmology
Volume101
Issue number1
DOIs
StatePublished - Jan 1983

ASJC Scopus subject areas

  • Ophthalmology

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