TY - JOUR
T1 - Blockade of ovulation in rats by inhibitory analogs of luteinizing hormone-releasing hormone
AU - De La Cruz, Antonio
AU - Coy, David H.
AU - Vilchez-Martinez, Jesus A.
AU - Arimura, Akira
AU - Schally, Andrew V.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - An antagonist of luteinizing hormone-releasing hormone (LH-RH), [D-Phe 2-Phe3-D-Phe6]-LH-RH (Phe, phenylalanine), suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in male rats in response to LH-RH for at least 4 hours. Three subcutaneous injections of 1 milligram of this antagonist into rats during proestrus completely suppressed ovulation, while a single injection of 1.5 milligrams per rat inhibited 95.3 percent of the preovulatory surge of LH, 84.2 percent of the FSH surge, and suppressed ovulation by 86.4 percent.
AB - An antagonist of luteinizing hormone-releasing hormone (LH-RH), [D-Phe 2-Phe3-D-Phe6]-LH-RH (Phe, phenylalanine), suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in male rats in response to LH-RH for at least 4 hours. Three subcutaneous injections of 1 milligram of this antagonist into rats during proestrus completely suppressed ovulation, while a single injection of 1.5 milligrams per rat inhibited 95.3 percent of the preovulatory surge of LH, 84.2 percent of the FSH surge, and suppressed ovulation by 86.4 percent.
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U2 - 10.1126/science.1108196
DO - 10.1126/science.1108196
M3 - Article
C2 - 1108196
AN - SCOPUS:0017106172
VL - 191
SP - 195
EP - 197
JO - Science
JF - Science
SN - 0036-8075
IS - 4223
ER -