Abstract
An antagonist of luteinizing hormone-releasing hormone (LH-RH), [D-Phe 2-Phe3-D-Phe6]-LH-RH (Phe, phenylalanine), suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in male rats in response to LH-RH for at least 4 hours. Three subcutaneous injections of 1 milligram of this antagonist into rats during proestrus completely suppressed ovulation, while a single injection of 1.5 milligrams per rat inhibited 95.3 percent of the preovulatory surge of LH, 84.2 percent of the FSH surge, and suppressed ovulation by 86.4 percent.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-197 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 191 |
| Issue number | 4223 |
| State | Published - 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
Cite this
De La Cruz, A., Coy, D. H., Vilchez-Martinez, J. A., Arimura, A., & Schally, A. V. (1976). Blockade of ovulation in rats by inhibitory analogs of luteinizing hormone-releasing hormone. Science, 191(4223), 195-197.