Blockade of ovulation in rats by inhibitory analogs of luteinizing hormone-releasing hormone

Antonio De La Cruz, David H. Coy, Jesus A. Vilchez-Martinez, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

An antagonist of luteinizing hormone-releasing hormone (LH-RH), [D-Phe 2-Phe3-D-Phe6]-LH-RH (Phe, phenylalanine), suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in male rats in response to LH-RH for at least 4 hours. Three subcutaneous injections of 1 milligram of this antagonist into rats during proestrus completely suppressed ovulation, while a single injection of 1.5 milligrams per rat inhibited 95.3 percent of the preovulatory surge of LH, 84.2 percent of the FSH surge, and suppressed ovulation by 86.4 percent.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalScience
Volume191
Issue number4223
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Blockade of ovulation in rats by inhibitory analogs of luteinizing hormone-releasing hormone'. Together they form a unique fingerprint.

  • Cite this