Abstract
The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.
| Original language | English |
|---|---|
| Pages (from-to) | 143-145 |
| Number of pages | 3 |
| Journal | Pflügers Archiv European Journal of Physiology |
| Volume | 364 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1976 |
| Externally published | Yes |
Fingerprint
Keywords
- Gating currents
- Nerve membrane
- Node of Ranvier
- Sodium channel
- Ultraviolet radiation
ASJC Scopus subject areas
- Physiology
Cite this
Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve. / Fox, J. M.; Neumcke, B.; Nonner, W.; Stämpfli, R.
In: Pflügers Archiv European Journal of Physiology, Vol. 364, No. 2, 01.01.1976, p. 143-145.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve
AU - Fox, J. M.
AU - Neumcke, B.
AU - Nonner, W.
AU - Stämpfli, R.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.
AB - The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.
KW - Gating currents
KW - Nerve membrane
KW - Node of Ranvier
KW - Sodium channel
KW - Ultraviolet radiation
UR - http://www.scopus.com/inward/record.url?scp=0017163834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017163834&partnerID=8YFLogxK
U2 - 10.1007/BF00585182
DO - 10.1007/BF00585182
M3 - Article
C2 - 986622
AN - SCOPUS:0017163834
VL - 364
SP - 143
EP - 145
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
SN - 0031-6768
IS - 2
ER -