Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve

J. M. Fox; B. Neumcke; W. Nonner; R. Stämpfli

doi:10.1007/BF00585182

Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve

J. M. Fox, B. Neumcke, W. Nonner, R. Stämpfli

Physiology & Biophysics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Pflügers Archiv European Journal of Physiology
Volume	364
Issue number	2
DOIs	https://doi.org/10.1007/BF00585182
State	Published - Jan 1 1976

Keywords

Gating currents
Nerve membrane
Node of Ranvier
Sodium channel
Ultraviolet radiation

ASJC Scopus subject areas

Physiology

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10.1007/BF00585182

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abstract = "The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.",

keywords = "Gating currents, Nerve membrane, Node of Ranvier, Sodium channel, Ultraviolet radiation",

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AU - Fox, J. M.

AU - Neumcke, B.

AU - Nonner, W.

AU - Stämpfli, R.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.

AB - The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.

KW - Gating currents

KW - Nerve membrane

KW - Node of Ranvier

KW - Sodium channel

KW - Ultraviolet radiation

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