Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve

J. M. Fox, B. Neumcke, W. Nonner, R. Stämpfli

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume364
Issue number2
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

Fingerprint

Ultraviolet radiation
Sodium
Radiation
Membranes
Ranvier's Nodes
Sodium Channels
Radiation Effects

Keywords

  • Gating currents
  • Nerve membrane
  • Node of Ranvier
  • Sodium channel
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Physiology

Cite this

Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve. / Fox, J. M.; Neumcke, B.; Nonner, W.; Stämpfli, R.

In: Pflügers Archiv European Journal of Physiology, Vol. 364, No. 2, 01.01.1976, p. 143-145.

Research output: Contribution to journalArticle

Fox, J. M. ; Neumcke, B. ; Nonner, W. ; Stämpfli, R. / Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve. In: Pflügers Archiv European Journal of Physiology. 1976 ; Vol. 364, No. 2. pp. 143-145.
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