Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival

Gislâine A. Martins, Luisa Cimmino, Jerry Liao, Erna Magnusdottir, Kathryn Calame

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

Mice with a T cell-specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasis and develop fatal colitis. In this study, we show that one critical activity of Blimp-1 in T cells is to repress IL-2, and that it does so by direct repression of Il2 transcription, and also by repression of Fos transcription. Using these mechanisms Blimp-1 participates in an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled. This activity of Blimp-1 is important for cytokine deprivation-induced T cell death and for attenuating T cell proliferation in antigen-specific responses both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)1959-1965
Number of pages7
JournalJournal of Experimental Medicine
Volume205
Issue number9
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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