Objective. The aim of this study was to evaluate the efficacy and the tolerability of the treatment of periungual and subungual warts with bleomycin subministered with the puncture technique. Methods. 80 patients affected by periungual and/or subungual warts (altogether 220 warts) entered the study. The bleomycin solution was dropped onto the wart, which was then rapidly punctured to the very base, approximately 40 times x 5 mm2 area of the wart. Patients were seen after three weeks, and the treatment was repeated if there were still signs of the wart, up to a maximum of three times. Results. 91% of the warts of 2 mm in thickness cleared after one treatment. 80% of the warts measuring more than 2 mm in thickness required 1 or 2 further treatments before complete clearing. 19 warts (with thickness >2 mm), were not cured by three cycles of bleopuncture therapy. No side effects were observed. Conclusions. Treatment of warts with bleomycin using the multiple puncture technique seems to be effective and safe. The minimal amount of bleomycin used and the essential restriction of the drug to the wart tissue explains the lack of toxicity problems. The main problem of the technique is the time of execution, which is 10-15 minutes for every wart; for this reason we recommend this treatment only for warts located in difficult anatomical areas, such as the periungual region.
|Translated title of the contribution||'Bleopuncture' therapy for the treatment of periungual warts|
|Number of pages||4|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|State||Published - Jun 21 1994|
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