Mouse fibroblasts (L-929) and human cells (HeLa and CCRF-CEM lymphoblasts) exposed to bleomycin in vitro for 20 hr showed a marked inhibition in the number of cells entering mitosis. Bleomycin-induced chromosomal aberrations were seen in cells from the three cultured lines and were mostly in the form of chromatid gaps, breaks, and fragments, and multiradial translocations. Human lymphoblasts (CCRF-CEM) were more resistant to the bleomycin-induced mitotic inhibition and chromosomal aberrations than the L-929 or HeLa cells. A small number of chromatid fragments and translocations were also seen in cells exposed to bleomycin in the G2 or post-DNA-synthetic part of the cell cycle.
|Original language||English (US)|
|Number of pages||5|
|State||Published - May 1973|
ASJC Scopus subject areas
- Cancer Research