Bleb-related ocular infection in children after trabeculectomy with mitomycin C

S. Waheed, D. C. Ritterband, D. S. Greenfield, J. M. Liebmann, P. A. Sidoti, R. Ritch

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Abstract

Objective: The purpose of the study is to report the clinical course of bleb-related ocular infection in children after trabeculectomy with adjunctive mitomycin C. Design: The study design was a retrospective review of all patients with a diagnosis of bleb-related ocular infection after trabeculectomy with adjunctive mitomycin C. Participants: Three children were identified in whom late postoperative bleb-related ocular infection developed. Intervention: Treatment consisted of vitreous biopsy with intravitreous antibiotic and corticosteroid injection and/or bleb culture with topical and intravenous antibiotic administration. Main Outcome Measures: Visual acuity and intraocular pressure were measured. Results: Bleb-related ocular infection developed an average of 16.7 ± 10.9 months after trabeculectomy (range, 4-23 months). The mean age at presentation was 7.0 ± 2.6 years (range, 4-10 years). Vitreous cultures were positive for staphylococci in two cases. A bleb culture from the third case also grew staphylococcus. All of the children recovered their initial vision after treatment of infection. However, one lost six lines of vision after a subsequent retinal detachment. Additional glaucoma surgery was required in one patient. Conclusions: Late bleb-related ocular infection may occur in children after trabeculectomy with mitomycin C and is characterized by abrupt onset, bleb infiltration, and rapid progression. Despite early preservation of vision after treatment of infection, significant late visual loss can occur.

Original languageEnglish (US)
Pages (from-to)2117-2120
Number of pages4
JournalOphthalmology
Volume104
Issue number12
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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    Waheed, S., Ritterband, D. C., Greenfield, D. S., Liebmann, J. M., Sidoti, P. A., & Ritch, R. (1997). Bleb-related ocular infection in children after trabeculectomy with mitomycin C. Ophthalmology, 104(12), 2117-2120. https://doi.org/10.1016/S0161-6420(97)30051-7