Bland thrombus association with tumour thrombus in renal cell carcinoma: Analysis of surgical significance and role of inferior vena caval interruption

Rajinikanth Ayyathurai, Michael Garcia-Roig, Michael A. Gorin, Javier González, Murugesan Manoharan, Bruce Kava, Mark S. Soloway, Gaetano Ciancio

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

OBJECTIVE: • To study the role of interruption of the inferior vena cava (IVC) in patients with renal cell carcinoma (RCC) and associated bland and tumour thrombi. METHODS: • We reviewed 129 consecutive patients with the preoperative diagnosis of RCC with tumour thrombus who underwent radical nephrectomy and tumour thrombectomy in one academic institution between May 1997 and February 2011. RESULTS: • Percentages of patients with levels I, II, III and IV tumour thrombus were 29%, 13%, 48% and 9%, respectively. • The perioperative mortality rate was 2.3%. There were 29 (22%) perioperative complications recorded. • In all, 19 patients underwent surgical interruption of the IVC by ligation or segmental resection, including one level II, 14 level III and four level IV thrombi. • A total of 15 patients (12%) had bland thrombus associated with the tumour thrombus; four of these underwent intraoperative IVC filter placement and eight underwent surgical IVC interruption. • Advanced level of tumour thrombus was the only significant factor predicting association of bland thrombus (odds ratio [ OR ] = 2.09, 95% confidence interval [ CI ] : 1.082 - 4.037, P = 0.028). • On multivariate analysis, level of thrombus (OR = 3.1, 95% CI: 1.30 - 7.74, P = 0.011) and association of bland thrombus (OR = 9.07, 95% CI: 2.42 - 34.01, P = 0.001) were significant factors for IVC interruption. CONCLUSIONS: • Surgical interruption of the IVC is a feasible option in selected patients with chronic IVC obstruction. Association of bland thrombus with tumour thrombus should alert the surgical team to the potential for a challenging surgery. • Precise preoperative imaging to assess the degree of venous obstruction and to help with differentiation between bland and tumour thrombus is key to achieving a surgical outcome with minimal morbidity.

Original languageEnglish
JournalBJU International
Volume110
Issue number11 B
DOIs
StatePublished - Dec 1 2012

Fingerprint

Venae Cavae
Renal Cell Carcinoma
Thrombosis
Inferior Vena Cava
Neoplasms
Odds Ratio
Confidence Intervals
Vena Cava Filters
Thrombectomy
Nephrectomy
Ligation

Keywords

  • Bland thrombus emboli
  • Inferior vena cava filter
  • Pulmonary emboli
  • Renal tumour
  • Tumour thrombus
  • Tumour thrombus emboli

ASJC Scopus subject areas

  • Urology

Cite this

Bland thrombus association with tumour thrombus in renal cell carcinoma : Analysis of surgical significance and role of inferior vena caval interruption. / Ayyathurai, Rajinikanth; Garcia-Roig, Michael; Gorin, Michael A.; González, Javier; Manoharan, Murugesan; Kava, Bruce; Soloway, Mark S.; Ciancio, Gaetano.

In: BJU International, Vol. 110, No. 11 B, 01.12.2012.

Research output: Contribution to journalArticle

Ayyathurai, Rajinikanth ; Garcia-Roig, Michael ; Gorin, Michael A. ; González, Javier ; Manoharan, Murugesan ; Kava, Bruce ; Soloway, Mark S. ; Ciancio, Gaetano. / Bland thrombus association with tumour thrombus in renal cell carcinoma : Analysis of surgical significance and role of inferior vena caval interruption. In: BJU International. 2012 ; Vol. 110, No. 11 B.
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abstract = "OBJECTIVE: • To study the role of interruption of the inferior vena cava (IVC) in patients with renal cell carcinoma (RCC) and associated bland and tumour thrombi. METHODS: • We reviewed 129 consecutive patients with the preoperative diagnosis of RCC with tumour thrombus who underwent radical nephrectomy and tumour thrombectomy in one academic institution between May 1997 and February 2011. RESULTS: • Percentages of patients with levels I, II, III and IV tumour thrombus were 29{\%}, 13{\%}, 48{\%} and 9{\%}, respectively. • The perioperative mortality rate was 2.3{\%}. There were 29 (22{\%}) perioperative complications recorded. • In all, 19 patients underwent surgical interruption of the IVC by ligation or segmental resection, including one level II, 14 level III and four level IV thrombi. • A total of 15 patients (12{\%}) had bland thrombus associated with the tumour thrombus; four of these underwent intraoperative IVC filter placement and eight underwent surgical IVC interruption. • Advanced level of tumour thrombus was the only significant factor predicting association of bland thrombus (odds ratio [ OR ] = 2.09, 95{\%} confidence interval [ CI ] : 1.082 - 4.037, P = 0.028). • On multivariate analysis, level of thrombus (OR = 3.1, 95{\%} CI: 1.30 - 7.74, P = 0.011) and association of bland thrombus (OR = 9.07, 95{\%} CI: 2.42 - 34.01, P = 0.001) were significant factors for IVC interruption. CONCLUSIONS: • Surgical interruption of the IVC is a feasible option in selected patients with chronic IVC obstruction. Association of bland thrombus with tumour thrombus should alert the surgical team to the potential for a challenging surgery. • Precise preoperative imaging to assess the degree of venous obstruction and to help with differentiation between bland and tumour thrombus is key to achieving a surgical outcome with minimal morbidity.",
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T2 - Analysis of surgical significance and role of inferior vena caval interruption

AU - Ayyathurai, Rajinikanth

AU - Garcia-Roig, Michael

AU - Gorin, Michael A.

AU - González, Javier

AU - Manoharan, Murugesan

AU - Kava, Bruce

AU - Soloway, Mark S.

AU - Ciancio, Gaetano

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N2 - OBJECTIVE: • To study the role of interruption of the inferior vena cava (IVC) in patients with renal cell carcinoma (RCC) and associated bland and tumour thrombi. METHODS: • We reviewed 129 consecutive patients with the preoperative diagnosis of RCC with tumour thrombus who underwent radical nephrectomy and tumour thrombectomy in one academic institution between May 1997 and February 2011. RESULTS: • Percentages of patients with levels I, II, III and IV tumour thrombus were 29%, 13%, 48% and 9%, respectively. • The perioperative mortality rate was 2.3%. There were 29 (22%) perioperative complications recorded. • In all, 19 patients underwent surgical interruption of the IVC by ligation or segmental resection, including one level II, 14 level III and four level IV thrombi. • A total of 15 patients (12%) had bland thrombus associated with the tumour thrombus; four of these underwent intraoperative IVC filter placement and eight underwent surgical IVC interruption. • Advanced level of tumour thrombus was the only significant factor predicting association of bland thrombus (odds ratio [ OR ] = 2.09, 95% confidence interval [ CI ] : 1.082 - 4.037, P = 0.028). • On multivariate analysis, level of thrombus (OR = 3.1, 95% CI: 1.30 - 7.74, P = 0.011) and association of bland thrombus (OR = 9.07, 95% CI: 2.42 - 34.01, P = 0.001) were significant factors for IVC interruption. CONCLUSIONS: • Surgical interruption of the IVC is a feasible option in selected patients with chronic IVC obstruction. Association of bland thrombus with tumour thrombus should alert the surgical team to the potential for a challenging surgery. • Precise preoperative imaging to assess the degree of venous obstruction and to help with differentiation between bland and tumour thrombus is key to achieving a surgical outcome with minimal morbidity.

AB - OBJECTIVE: • To study the role of interruption of the inferior vena cava (IVC) in patients with renal cell carcinoma (RCC) and associated bland and tumour thrombi. METHODS: • We reviewed 129 consecutive patients with the preoperative diagnosis of RCC with tumour thrombus who underwent radical nephrectomy and tumour thrombectomy in one academic institution between May 1997 and February 2011. RESULTS: • Percentages of patients with levels I, II, III and IV tumour thrombus were 29%, 13%, 48% and 9%, respectively. • The perioperative mortality rate was 2.3%. There were 29 (22%) perioperative complications recorded. • In all, 19 patients underwent surgical interruption of the IVC by ligation or segmental resection, including one level II, 14 level III and four level IV thrombi. • A total of 15 patients (12%) had bland thrombus associated with the tumour thrombus; four of these underwent intraoperative IVC filter placement and eight underwent surgical IVC interruption. • Advanced level of tumour thrombus was the only significant factor predicting association of bland thrombus (odds ratio [ OR ] = 2.09, 95% confidence interval [ CI ] : 1.082 - 4.037, P = 0.028). • On multivariate analysis, level of thrombus (OR = 3.1, 95% CI: 1.30 - 7.74, P = 0.011) and association of bland thrombus (OR = 9.07, 95% CI: 2.42 - 34.01, P = 0.001) were significant factors for IVC interruption. CONCLUSIONS: • Surgical interruption of the IVC is a feasible option in selected patients with chronic IVC obstruction. Association of bland thrombus with tumour thrombus should alert the surgical team to the potential for a challenging surgery. • Precise preoperative imaging to assess the degree of venous obstruction and to help with differentiation between bland and tumour thrombus is key to achieving a surgical outcome with minimal morbidity.

KW - Bland thrombus emboli

KW - Inferior vena cava filter

KW - Pulmonary emboli

KW - Renal tumour

KW - Tumour thrombus

KW - Tumour thrombus emboli

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