Bladder Progenitor Cells and Their Use for Tissue Engineering

Anthony Atala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gastrointestinal segments are commonly used as tissues for bladder replacement or repair. These include matrices for tissue regeneration and tissue engineering using cell transplantation. Engineering tissue using selective cell transplantation provides the means to create functional, new bladder segments. Tissue engineering technologies have already been clinically applied to the bladder by using injectable cells for the treatment of vesicoureteral reflux and urinary incontinence. The approach, followed to bioengineer bladder tissue, involves the eventual use of autologous cells, thus avoiding rejection: A biopsy of tissue is obtained from the host, and the cells are dissociated and expanded in vitro, reattached to a matrix, and implanted into the same host. The success of using cell transplantation strategies for bladder reconstruction depends on the ability to use donor tissue efficiently and to provide the right conditions for longterm survival, differentiation, and growth. The supporting matrix is composed of biodegradable artificial or natural polymers that can allow cell survival by diffusion of nutrients across short distances once the cell support matrix is implanted.

Original languageEnglish (US)
Title of host publicationHandbook of Stem Cells
PublisherElsevier Inc.
Pages565-570
Number of pages6
Volume2
ISBN (Print)9780080533735, 9780124366435
DOIs
StatePublished - Sep 14 2004
Externally publishedYes

Fingerprint

Tissue Engineering
Tissue engineering
Urinary Bladder
Stem Cells
Tissue
Transplantation (surgical)
Cell Transplantation
Natural polymers
Tissue regeneration
Biopsy
Engineering technology
Vesico-Ureteral Reflux
Nutrients
Urinary Incontinence
Repair
Cells
Regeneration
Cell Survival
Polymers
Tissue Donors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Atala, A. (2004). Bladder Progenitor Cells and Their Use for Tissue Engineering. In Handbook of Stem Cells (Vol. 2, pp. 565-570). Elsevier Inc.. https://doi.org/10.1016/B978-012436643-5/50140-1

Bladder Progenitor Cells and Their Use for Tissue Engineering. / Atala, Anthony.

Handbook of Stem Cells. Vol. 2 Elsevier Inc., 2004. p. 565-570.

Research output: Chapter in Book/Report/Conference proceedingChapter

Atala, A 2004, Bladder Progenitor Cells and Their Use for Tissue Engineering. in Handbook of Stem Cells. vol. 2, Elsevier Inc., pp. 565-570. https://doi.org/10.1016/B978-012436643-5/50140-1
Atala A. Bladder Progenitor Cells and Their Use for Tissue Engineering. In Handbook of Stem Cells. Vol. 2. Elsevier Inc. 2004. p. 565-570 https://doi.org/10.1016/B978-012436643-5/50140-1
Atala, Anthony. / Bladder Progenitor Cells and Their Use for Tissue Engineering. Handbook of Stem Cells. Vol. 2 Elsevier Inc., 2004. pp. 565-570
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