Bladder growth and development after complete primary repair of bladder exstrophy in the newborn with comparison to staged approach

Joseph G. Borer, Patricio C. Gargollo, Daniel D. Kinnamon, Stuart B. Bauer, Shahram Khoshbin, W. Hardy Hendren, Craig A. Peters, David A. Diamond, Anthony Atala, Sandy Chin, Alan B. Retik, Steve Docimo, Michael Mitchell, Henri Lottmann, Ranjiv Mathews

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: We assessed bladder growth and dynamics following complete primary repair of bladder exstrophy (CPRE) compared to the staged approach. Materials and Methods: We reviewed the records of 16 boys and 7 girls who underwent CPRE within 3 days of life from 1996 to 2004 and compared them to the records of 8 boys and 6 girls treated with a staged repair from 1979 to 1996. Screening methods included voiding cystourethrogram, radionuclide cystogram and urodynamic study. We estimated growth curves for bladder capacity following repair in each group, and compared percent predicted bladder capacity (PPBC), compliance and detrusor overactivity between the CPRE and staged repair groups following bladder neck reconstruction. Results: Bladder capacity in the staged repair group was 69.8 ml (95% CI 46.7-104.4) immediately after bladder neck reconstruction and increased by 15.0% per year thereafter (95% CI 6.2-24.5, p = 0.002). In the CPRE group bladder capacity was 29.0 ml (95% CI 21.3-39.5) initially and increased by 28.9% per year thereafter (95% CI 17.4-41.5, p < 0.001). PPBC started at 45.6% (95% CI 35.7-55.5) and increased 1.2% per year (95% CI -1.1-3.5, p = 0.29) following repair for all genders and surgery groups. Compliance was 124.4% (95% CI 22.6-310.7, p = 0.01) greater in the CPRE group at all times following repair. Detrusor overactivity was present in 0 of 19 patients in the CPRE group and 6 of 13 (46%) in the staged group (exact p = 0.002). Conclusions: Within the CPRE group bladder stability was universal, and sphincter electromyography was normal suggesting no neuromuscular compromise of the pelvic floor. At early followup, our results suggest that PPBC is equivalent irrespective of gender or management. Further objective evaluation is needed in both groups.

Original languageEnglish
Pages (from-to)1553-1558
Number of pages6
JournalJournal of Urology
Volume174
Issue number4 II
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

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Bladder Exstrophy
Growth and Development
Urinary Bladder
Newborn Infant
Compliance
Pelvic Floor
Urodynamics
Electromyography
Growth
Radioisotopes

Keywords

  • Bladder exstrophy
  • Reconstructive surgical procedures
  • Urodynamics

ASJC Scopus subject areas

  • Urology

Cite this

Borer, J. G., Gargollo, P. C., Kinnamon, D. D., Bauer, S. B., Khoshbin, S., Hendren, W. H., ... Mathews, R. (2005). Bladder growth and development after complete primary repair of bladder exstrophy in the newborn with comparison to staged approach. Journal of Urology, 174(4 II), 1553-1558. https://doi.org/10.1097/01.ju.0000176636.85476.5d

Bladder growth and development after complete primary repair of bladder exstrophy in the newborn with comparison to staged approach. / Borer, Joseph G.; Gargollo, Patricio C.; Kinnamon, Daniel D.; Bauer, Stuart B.; Khoshbin, Shahram; Hendren, W. Hardy; Peters, Craig A.; Diamond, David A.; Atala, Anthony; Chin, Sandy; Retik, Alan B.; Docimo, Steve; Mitchell, Michael; Lottmann, Henri; Mathews, Ranjiv.

In: Journal of Urology, Vol. 174, No. 4 II, 01.10.2005, p. 1553-1558.

Research output: Contribution to journalArticle

Borer, JG, Gargollo, PC, Kinnamon, DD, Bauer, SB, Khoshbin, S, Hendren, WH, Peters, CA, Diamond, DA, Atala, A, Chin, S, Retik, AB, Docimo, S, Mitchell, M, Lottmann, H & Mathews, R 2005, 'Bladder growth and development after complete primary repair of bladder exstrophy in the newborn with comparison to staged approach', Journal of Urology, vol. 174, no. 4 II, pp. 1553-1558. https://doi.org/10.1097/01.ju.0000176636.85476.5d
Borer, Joseph G. ; Gargollo, Patricio C. ; Kinnamon, Daniel D. ; Bauer, Stuart B. ; Khoshbin, Shahram ; Hendren, W. Hardy ; Peters, Craig A. ; Diamond, David A. ; Atala, Anthony ; Chin, Sandy ; Retik, Alan B. ; Docimo, Steve ; Mitchell, Michael ; Lottmann, Henri ; Mathews, Ranjiv. / Bladder growth and development after complete primary repair of bladder exstrophy in the newborn with comparison to staged approach. In: Journal of Urology. 2005 ; Vol. 174, No. 4 II. pp. 1553-1558.
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abstract = "Purpose: We assessed bladder growth and dynamics following complete primary repair of bladder exstrophy (CPRE) compared to the staged approach. Materials and Methods: We reviewed the records of 16 boys and 7 girls who underwent CPRE within 3 days of life from 1996 to 2004 and compared them to the records of 8 boys and 6 girls treated with a staged repair from 1979 to 1996. Screening methods included voiding cystourethrogram, radionuclide cystogram and urodynamic study. We estimated growth curves for bladder capacity following repair in each group, and compared percent predicted bladder capacity (PPBC), compliance and detrusor overactivity between the CPRE and staged repair groups following bladder neck reconstruction. Results: Bladder capacity in the staged repair group was 69.8 ml (95{\%} CI 46.7-104.4) immediately after bladder neck reconstruction and increased by 15.0{\%} per year thereafter (95{\%} CI 6.2-24.5, p = 0.002). In the CPRE group bladder capacity was 29.0 ml (95{\%} CI 21.3-39.5) initially and increased by 28.9{\%} per year thereafter (95{\%} CI 17.4-41.5, p < 0.001). PPBC started at 45.6{\%} (95{\%} CI 35.7-55.5) and increased 1.2{\%} per year (95{\%} CI -1.1-3.5, p = 0.29) following repair for all genders and surgery groups. Compliance was 124.4{\%} (95{\%} CI 22.6-310.7, p = 0.01) greater in the CPRE group at all times following repair. Detrusor overactivity was present in 0 of 19 patients in the CPRE group and 6 of 13 (46{\%}) in the staged group (exact p = 0.002). Conclusions: Within the CPRE group bladder stability was universal, and sphincter electromyography was normal suggesting no neuromuscular compromise of the pelvic floor. At early followup, our results suggest that PPBC is equivalent irrespective of gender or management. Further objective evaluation is needed in both groups.",
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AU - Gargollo, Patricio C.

AU - Kinnamon, Daniel D.

AU - Bauer, Stuart B.

AU - Khoshbin, Shahram

AU - Hendren, W. Hardy

AU - Peters, Craig A.

AU - Diamond, David A.

AU - Atala, Anthony

AU - Chin, Sandy

AU - Retik, Alan B.

AU - Docimo, Steve

AU - Mitchell, Michael

AU - Lottmann, Henri

AU - Mathews, Ranjiv

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N2 - Purpose: We assessed bladder growth and dynamics following complete primary repair of bladder exstrophy (CPRE) compared to the staged approach. Materials and Methods: We reviewed the records of 16 boys and 7 girls who underwent CPRE within 3 days of life from 1996 to 2004 and compared them to the records of 8 boys and 6 girls treated with a staged repair from 1979 to 1996. Screening methods included voiding cystourethrogram, radionuclide cystogram and urodynamic study. We estimated growth curves for bladder capacity following repair in each group, and compared percent predicted bladder capacity (PPBC), compliance and detrusor overactivity between the CPRE and staged repair groups following bladder neck reconstruction. Results: Bladder capacity in the staged repair group was 69.8 ml (95% CI 46.7-104.4) immediately after bladder neck reconstruction and increased by 15.0% per year thereafter (95% CI 6.2-24.5, p = 0.002). In the CPRE group bladder capacity was 29.0 ml (95% CI 21.3-39.5) initially and increased by 28.9% per year thereafter (95% CI 17.4-41.5, p < 0.001). PPBC started at 45.6% (95% CI 35.7-55.5) and increased 1.2% per year (95% CI -1.1-3.5, p = 0.29) following repair for all genders and surgery groups. Compliance was 124.4% (95% CI 22.6-310.7, p = 0.01) greater in the CPRE group at all times following repair. Detrusor overactivity was present in 0 of 19 patients in the CPRE group and 6 of 13 (46%) in the staged group (exact p = 0.002). Conclusions: Within the CPRE group bladder stability was universal, and sphincter electromyography was normal suggesting no neuromuscular compromise of the pelvic floor. At early followup, our results suggest that PPBC is equivalent irrespective of gender or management. Further objective evaluation is needed in both groups.

AB - Purpose: We assessed bladder growth and dynamics following complete primary repair of bladder exstrophy (CPRE) compared to the staged approach. Materials and Methods: We reviewed the records of 16 boys and 7 girls who underwent CPRE within 3 days of life from 1996 to 2004 and compared them to the records of 8 boys and 6 girls treated with a staged repair from 1979 to 1996. Screening methods included voiding cystourethrogram, radionuclide cystogram and urodynamic study. We estimated growth curves for bladder capacity following repair in each group, and compared percent predicted bladder capacity (PPBC), compliance and detrusor overactivity between the CPRE and staged repair groups following bladder neck reconstruction. Results: Bladder capacity in the staged repair group was 69.8 ml (95% CI 46.7-104.4) immediately after bladder neck reconstruction and increased by 15.0% per year thereafter (95% CI 6.2-24.5, p = 0.002). In the CPRE group bladder capacity was 29.0 ml (95% CI 21.3-39.5) initially and increased by 28.9% per year thereafter (95% CI 17.4-41.5, p < 0.001). PPBC started at 45.6% (95% CI 35.7-55.5) and increased 1.2% per year (95% CI -1.1-3.5, p = 0.29) following repair for all genders and surgery groups. Compliance was 124.4% (95% CI 22.6-310.7, p = 0.01) greater in the CPRE group at all times following repair. Detrusor overactivity was present in 0 of 19 patients in the CPRE group and 6 of 13 (46%) in the staged group (exact p = 0.002). Conclusions: Within the CPRE group bladder stability was universal, and sphincter electromyography was normal suggesting no neuromuscular compromise of the pelvic floor. At early followup, our results suggest that PPBC is equivalent irrespective of gender or management. Further objective evaluation is needed in both groups.

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