Bisphosphonates and Bisphosphonate Induced Osteonecrosis

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Abstract

Bisphosphonate-induced osteonecrosis of the jaws is the correct term for this real drug complication that most dental practitioners face. All nitrogen-containing bisphosphonates pose a risk, which is related to the route of administration, the potency of the bisphosphonate, and the duration of use. Although intravenous bisphosphonate-induced osteonecrosis of the jaws is mostly permanent, most cases can be prevented or managed if they develop, with only a few cases requiring resection for resolution. Oral bisphosphonate-induced osteonecrosis of the jaws also can be prevented with knowledge of the risk level related to the duration of use and the C-terminal telopeptide blood test results. Most cases can be resolved with a drug holiday either spontaneously or via straightforward débridement.

Original languageEnglish (US)
Pages (from-to)487-498
Number of pages12
JournalOral and Maxillofacial Surgery Clinics of North America
Volume19
Issue number4
DOIs
StatePublished - Nov 1 2007

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ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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