Biphasic blood pressure response to neuropeptide Y in anesthetized rats

Lars Grundemar, Claes R Wahlestedt, Gregory H. Shen, Zofia Zukowska-Grojec, Rolf Håkanson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effects of neuropeptide Y (NPY) on systemic arterial blood pressure and heart rate were studied in anesthetized intact and pithed rats. I.v. doses of NPY (0.3-30 nmol/kg) raised the mean arterial blood pressure dose dependently. At doses of >/ 3.0 nmol/kg, the initial pressor response was followed by a dose-dependent fall in blood pressure in intact and pithed rats. The depressor response was accompanied 1-2 min after the NPY injection by a slight increase in heart rate in pithed rats but not in intact rats, and 10 min after the injection by a decrease in heart rate in intact rats. After repeated injections of NPY, the depressor effect vanished, whereas the integrated pressor response over time was markedly enhanced. After pretreatment with the histamine H1-receptor antagonist, mepyramine, or with the histamine liberator, compound 48/80, the pressor response to NPY remained but the depressor response disappeared. We suggest that the marked fall in blood pressure can be attributed to NPY-evoked histamine release from mast cells.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalEuropean Journal of Pharmacology
Volume179
Issue number1-2
DOIs
StatePublished - Apr 10 1990
Externally publishedYes

Fingerprint

Neuropeptide Y
Blood Pressure
Arterial Pressure
Heart Rate
Injections
Histamine H1 Antagonists
p-Methoxy-N-methylphenethylamine
Pyrilamine
Histamine Release
Mast Cells
Histamine

Keywords

  • Hypertension
  • Hypotension
  • Neuropeptide Y (NPY)
  • NPY receptors
  • Tachyphylaxis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Biphasic blood pressure response to neuropeptide Y in anesthetized rats. / Grundemar, Lars; Wahlestedt, Claes R; Shen, Gregory H.; Zukowska-Grojec, Zofia; Håkanson, Rolf.

In: European Journal of Pharmacology, Vol. 179, No. 1-2, 10.04.1990, p. 83-87.

Research output: Contribution to journalArticle

Grundemar, Lars ; Wahlestedt, Claes R ; Shen, Gregory H. ; Zukowska-Grojec, Zofia ; Håkanson, Rolf. / Biphasic blood pressure response to neuropeptide Y in anesthetized rats. In: European Journal of Pharmacology. 1990 ; Vol. 179, No. 1-2. pp. 83-87.
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