Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea

Bianca M. Piraccini, Enzo Berardesca, Gabriella Fabbrocini, Giuseppe Micali, Antonella Tosti

Research output: Contribution to journalArticle

Abstract

One of the most common micronutrient deficiencies with cutaneous findings is the vitamin B, also known as biotin, deficiency. Biotin deficiency may be due to congenital lack of biotinidase, or acquired following some conditions that interfere with its absorption, such as inflammatory bowel disorders, a diet too rich in avidin, magnesium deficiency, smoking habit and treatment with broad-spectrum antibiotics, anticonvulsants and sulfonamides. This review highlights the role of biotin in the most common skin disorders such associated with biotin deficiency and an approach to their treatment. Biotin administration may improve the treatment of hair loss when deficiency is detected on the basis of a careful patient history, clinical examination and the determination of serum biotin levels. The use of biotin is rationale in seborrheic dermatitis as the vitamin intercepts the main metabolic pathways underlying the pathogenesis of the disease. Treatment with biotin could also be useful in comedonal acne characterized by a high rate of seborrhea, and may be helpful for acne treated with topical retinoids, contributing to the control of flaking and irritation. The tolerability of biotin is excellent and there is no risk of hypervitaminosis even in the case of high doses. It is important that administration is controlled by physicians and follows a medical diagnosis and prescription. Correct doses used in dermatological conditions are safe and are not at risk of interference with laboratory tests.

Original languageEnglish (US)
Pages (from-to)557-566
Number of pages10
JournalGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
Volume154
Issue number5
DOIs
StatePublished - Oct 1 2019

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Biotin
Skin
Seborrheic Dermatitis
Acne Vulgaris
Biotinidase
Therapeutics
Magnesium Deficiency
Vitamin B Complex
Avidin
Micronutrients
Alopecia
Sulfonamides
Retinoids
Metabolic Networks and Pathways
Vitamins
Anticonvulsants
Habits
Prescriptions
Smoking
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Dermatology

Cite this

Biotin : overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea. / Piraccini, Bianca M.; Berardesca, Enzo; Fabbrocini, Gabriella; Micali, Giuseppe; Tosti, Antonella.

In: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, Vol. 154, No. 5, 01.10.2019, p. 557-566.

Research output: Contribution to journalArticle

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