Biosensors for quorum chemical signaling molecules: Implications of bacterial communication in gastrointestinal disorders

Anjali Kumari, Patrizia Pasini, Sapna K. Deo, Deborah Flomenhoft, Harohalli Shashidhar, Sylvia Daunert

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The role of bacteria in causing biofouling and a wide variety of health imbalances has been long established. Moreover, bacterial load plays a fundamental role in these processes. Bacteria regulate expression of certain specialized genes, including certain behaviors/phenotypes, as a function of their population density. They employ chemical language, i.e., signaling molecules for their communication and group-based coordination. This phenomenon is known as quorum sensing (QS). The signaling molecules generally are N-acylated homoserine lactones (AHLs) in Gram-negative bacteria, small peptides in Gram-positive bacteria and a furanosyl borate diester, which is common to both types of bacteria. Thus, to better elucidate the mechanism of pathogenicity in bacteria, it is important to understand bacterial communication. The first step toward that end is to be able to detect the signaling molecules in a sensitive and selective manner. We hypothesize that the levels of these quorum sensing molecules (QSMs) in individuals may correlate with their health status, thus QSMs may be significant as biomarkers of diseases. These biomarkers may serve in the monitoring of disease activity and a patient's health. In that regard, we have developed whole- cell sensing systems for the detection of AHLs. Further,.

Original languageEnglish (US)
Title of host publicationMicrobial Surfaces
Subtitle of host publicationStructure, Interactions, and Reactivity
PublisherAmerican Chemical Society
Pages13-27
Number of pages15
ISBN (Print)9780841274303
DOIs
StatePublished - May 30 2008
Externally publishedYes

Publication series

NameACS Symposium Series
Volume984
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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