Bioreactors for development of tissue engineered heart valves

Joel L. Berry, Julie A. Steen, J. Koudy Williams, James E. Jordan, Anthony Atala, James J. Yoo

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvantages including morbidity associated with long-term anticoagulation and limited durability necessitating repeat operations. The ideal substitute would be widely available and technically implantable for most cardiac surgeons, have normal hemodynamic performance, low risk for structural degeneration, thrombo-embolism and endocarditis, and growth potential for pediatric patients. Tissue engineered heart valves hold promise as a viable substitute to outperform existing valve replacements. An essential component to the development of tissue engineered heart valves is a bioreactor. It is inside the bioreactor that the scaffold and cells are gradually conditioned to the biochemical and mechanical environment of the valve to be replaced.

Original languageEnglish (US)
Pages (from-to)3272-3279
Number of pages8
JournalAnnals of biomedical engineering
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2010

Keywords

  • Bioreactor
  • Endothelial cells
  • Heart valves
  • Preconditioning
  • Valvular cells

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Berry, J. L., Steen, J. A., Koudy Williams, J., Jordan, J. E., Atala, A., & Yoo, J. J. (2010). Bioreactors for development of tissue engineered heart valves. Annals of biomedical engineering, 38(11), 3272-3279. https://doi.org/10.1007/s10439-010-0148-6