Bioprinting of organs for toxicology testing

Hyun Wook Kang, Anthony Atala, James J. Yoo

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Toxicology testing of new drugs is generally performed in animal models. While this traditional approach is instrumental in gaining valuable information from an in vivo model, a number of issues arise with this type of testing such as questionable results, a large financial investment, and ethical considerations. Alternative approaches to animal testing include the use of organoids, which are biological models for specific organs or tissues that are composed of living cells or biomaterials. The organoid should have similar functionality with the native organ or tissue for toxicology testing to be successful. Bioprinting allows for the production of a designed architecture consisting of multiple types of living cells in combination with a variety of biomaterials and can be used in the construction of an organoid that mimics the native organ or tissue. In this chapter, bioprinting technology and its application for the development of new organoids will be discussed.

Original languageEnglish (US)
Title of host publicationEssentials of 3D Biofabrication and Translation
PublisherElsevier Inc.
Pages179-186
Number of pages8
ISBN (Print)9780128010150, 9780128009727
DOIs
StatePublished - Aug 7 2015
Externally publishedYes

Keywords

  • Animal model
  • Bioprinting
  • Organoid
  • Toxicology testing

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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