Bioprinting of organoids

Carlos Kengla, Anthony Atala, Sang Jin Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Three-dimensional (3D) bioprinting technology was developed to allow the construction of biological tissue constructs that mimic the structure and function of native tissues or organs. This technology makes it possible to precisely place various cell types with hydrogel-based bioinks in a 3D architecture. The hypothesis driving the development of 3D bioprinted tissue constructs is that by precisely placing cells in relation to each other, an environment that encourages physiologically relevant cues can be created, resulting in a tissue construct with appropriate functionality. Consequently, the bioprinted organoids could provide more anatomical and functional similarity of human tissues or organs for pharmacokinetics and pharmacodynamics models. The bioprinted tissue organoid structures will play an increasing role in drug discovery and therapeutics over the next decade. This chapter will discuss these bioprinting technologies and their applications in organoid printing.

Original languageEnglish (US)
Title of host publicationEssentials of 3D Biofabrication and Translation
PublisherElsevier Inc.
Pages271-282
Number of pages12
ISBN (Print)9780128010150, 9780128009727
DOIs
StatePublished - Aug 7 2015
Externally publishedYes

Keywords

  • Bioinks
  • Bioprinting
  • Drug screening
  • Hydrogel
  • Organoid
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Kengla, C., Atala, A., & Lee, S. J. (2015). Bioprinting of organoids. In Essentials of 3D Biofabrication and Translation (pp. 271-282). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800972-7.00015-3