TY - JOUR
T1 - Biomolecular Material Recognition in Two Dimensions
T2 - Peptide Binding to Graphene, h-BN, and MoS2 Nanosheets as Unique Bioconjugates
AU - Walsh, Tiffany R.
AU - Knecht, Marc R.
N1 - Funding Information:
This material is based upon work supported by the Air Force Office of Scientific Research, Grant FA9550-18-1-0329.
PY - 2019/11/20
Y1 - 2019/11/20
N2 - Two-dimensional nanosheet-based materials such as graphene, hexagonal boron nitride, and MoS2 represent intriguing structures for a variety of biological applications ranging from biosensing to nanomedicine. Recent advances have demonstrated that peptides can be identified with affinity for these three materials, thus generating a highly unique bioconjugate interfacial system. This Review focuses on recent advances in the formation of bioconjugates of these types, paying particular attention to the structure/function relationship of the peptide overlayer. This is achieved through the amino acid composition of the nanosheet binding peptides, thus allowing for precise control over the properties of the final materials. Such bioconjugate systems offer rapid advances via direct property control that remain difficult to achieve for biological applications using nonbiological approaches.
AB - Two-dimensional nanosheet-based materials such as graphene, hexagonal boron nitride, and MoS2 represent intriguing structures for a variety of biological applications ranging from biosensing to nanomedicine. Recent advances have demonstrated that peptides can be identified with affinity for these three materials, thus generating a highly unique bioconjugate interfacial system. This Review focuses on recent advances in the formation of bioconjugates of these types, paying particular attention to the structure/function relationship of the peptide overlayer. This is achieved through the amino acid composition of the nanosheet binding peptides, thus allowing for precise control over the properties of the final materials. Such bioconjugate systems offer rapid advances via direct property control that remain difficult to achieve for biological applications using nonbiological approaches.
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U2 - 10.1021/acs.bioconjchem.9b00593
DO - 10.1021/acs.bioconjchem.9b00593
M3 - Review article
C2 - 31593454
AN - SCOPUS:85075647980
VL - 30
SP - 2727
EP - 2750
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 11
ER -