Biomechanical model of corneal transplantation

Delia Cabrera DeBuc, A. M. Niazy, R. M. Kurtz, G. P. Djotyan, T. Juhasz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PURPOSE: Refractive consequences of corneal transplants are analyzed using corneal biomechanical models assuming homogeneous and inhomogeneous stiffness distributions across the cornea. Additionally, refractive effects of grafts combined with volume removal procedures are also evaluated to develop methods to reduce postoperative refractive management of patients. METHODS: Refinements of a two-dimensional finite element model are applied to simulate the biomechanical and refractive effects of different corneal transplant procedures: anterior lamellar keratoplasty, posterior lamellar keratoplasty, and penetrating keratoplasty. The models are based on a nonlinearly elastic, isotropic formulation. Predictions are compared with published clinical data. RESULTS: The model simulating the penetrating keratoplasty procedure predicts more change in the postoperative corneal curvature than models simulating anterior lamellar keratoplasty or posterior lamellar keratoplasty procedures. When a lenticle-shaped tissue with a central thickness of 50 microns and a diameter of 4 mm is removed from the anterior corneal surface along with the anterior lamellar keratoplasty or posterior lamellar keratoplasty, the models predict a refractive correction of -8.6 and -8.9 diopters, respectively. CONCLUSIONS: Simulations indicate that a posterior lamellar keratoplasty procedure is preferable for obtaining a better corneal curvature profile, eliminating the need for specific secondary treatments.

Original languageEnglish (US)
Pages (from-to)293-302
Number of pages10
JournalJournal of Refractive Surgery
Volume22
Issue number3
StatePublished - Mar 2006

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Corneal Transplantation
Penetrating Keratoplasty
Transplants
Cornea

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Cabrera DeBuc, D., Niazy, A. M., Kurtz, R. M., Djotyan, G. P., & Juhasz, T. (2006). Biomechanical model of corneal transplantation. Journal of Refractive Surgery, 22(3), 293-302.

Biomechanical model of corneal transplantation. / Cabrera DeBuc, Delia; Niazy, A. M.; Kurtz, R. M.; Djotyan, G. P.; Juhasz, T.

In: Journal of Refractive Surgery, Vol. 22, No. 3, 03.2006, p. 293-302.

Research output: Contribution to journalArticle

Cabrera DeBuc, D, Niazy, AM, Kurtz, RM, Djotyan, GP & Juhasz, T 2006, 'Biomechanical model of corneal transplantation', Journal of Refractive Surgery, vol. 22, no. 3, pp. 293-302.
Cabrera DeBuc D, Niazy AM, Kurtz RM, Djotyan GP, Juhasz T. Biomechanical model of corneal transplantation. Journal of Refractive Surgery. 2006 Mar;22(3):293-302.
Cabrera DeBuc, Delia ; Niazy, A. M. ; Kurtz, R. M. ; Djotyan, G. P. ; Juhasz, T. / Biomechanical model of corneal transplantation. In: Journal of Refractive Surgery. 2006 ; Vol. 22, No. 3. pp. 293-302.
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