Biomechanical evaluation of the cylindrical TI mesh cage for the treatment of segmental defects of the tibia

P. A. Ostermann, L. L. Latta, L. Biedermann, E. L. Milne

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: A recent report showed successful management of large diaphyseal segmental bone defects with titanium mesh cages and intramedullary nails. The purpose of the study was a quantitative evaluation of the of the mechanical role of a cylindrical titanium mesh cage and an intramedullary nail when used for the treatment of significant segmental defects of the tibia. Methods: : 28 adult rats after sustaining closed, mid shaft femur fracture, were bled to maintain a mean arterial pressure of 40 mmHg for 20 minutes while monitoring blood oxygen content. Groups: 1) no therapy; 2) 15 ml/kg Hextend infusion over 40 minutes; 3) 3 mg/kg BIIB513 (NHE-1 inhibitor) + 15 ml/kg Hextend infusion over 40 minutes. After 4 hours, the animals who survived received a second infusion of Hextend. Results: All animals in the no therapy group died within 2 hours. Group 3 showed improved hemodynamic response to fluid resuscitation, increased blood oxygen content, prevented metabolic acidosis, and improved 6 hour survival, 42%, compared to group 3, 80%. NHE-1 inhibition also resulted in reduced plasma levels of TNF-α, ICAM-1 and C-reactive protein, and attenuated neutrophil infiltration in the liver. There were no morhpologic changes found in any of the tissue samples at this early time period. Conclusion: NHE inhibition prevented early death caused by cardiac arrest, and multiple organ failure by inhibiting neutrophil infiltration and NF-(B activation, thereby, reducing systemic inflammation in a model of severe hemorrhagic shock and fracture in a rat.

Original languageEnglish (US)
Title of host publication25th Southern Biomedical Engineering Conference 2009
Pages95-96
Number of pages2
DOIs
StatePublished - Nov 6 2009
Event25th Southern Biomedical Engineering Conference 2009 - Miami, FL, United States
Duration: May 15 2009May 17 2009

Publication series

NameIFMBE Proceedings
Volume24
ISSN (Print)1680-0737

Other

Other25th Southern Biomedical Engineering Conference 2009
CountryUnited States
CityMiami, FL
Period5/15/095/17/09

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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    Ostermann, P. A., Latta, L. L., Biedermann, L., & Milne, E. L. (2009). Biomechanical evaluation of the cylindrical TI mesh cage for the treatment of segmental defects of the tibia. In 25th Southern Biomedical Engineering Conference 2009 (pp. 95-96). (IFMBE Proceedings; Vol. 24). https://doi.org/10.1007/978-3-642-01697-4_33