Biomaterials for tissue engineering

Byung Soo Kim, Carlos E. Baez, Anthony Atala

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Biomaterials play a critical role in the engineering of new functional genitourinary tissues for the replacement of lost or malfunctioning tissues. They provide a temporary scaffolding to guide new tissue growth and organization and may provide bioactive signals (e.g., cell-adhesion peptides and growth factors) required for the retention of tissue-specific gene expression. A variety of biomaterials, which can be classified into three types - naturally derived materials (e.g., collagen and alginate), acellular tissue matrices (e.g., bladder submucosa and small-intestinal submucosa), and synthetic polymers [e.g., polyglycolic acid, polylactic acid, and poly(lactic-co-glycolic acid)] - have proved to be useful in the reconstruction of a number of genitourinary tissues in animal models. Some of these materials are currently being used clinically for genitourinary applications. Ultimately, the development or selection of appropriate biomaterials may allow the engineering of multiple types of functional genitourinary tissues.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalWorld Journal of Urology
Volume18
Issue number1
StatePublished - Dec 1 2000
Externally publishedYes

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Biocompatible Materials
Tissue Engineering
Polyglycolic Acid
Intercellular Signaling Peptides and Proteins
Polymers
Urinary Bladder
Collagen
Animal Models
Gene Expression
Peptides
Growth

ASJC Scopus subject areas

  • Urology

Cite this

Kim, B. S., Baez, C. E., & Atala, A. (2000). Biomaterials for tissue engineering. World Journal of Urology, 18(1), 2-9.

Biomaterials for tissue engineering. / Kim, Byung Soo; Baez, Carlos E.; Atala, Anthony.

In: World Journal of Urology, Vol. 18, No. 1, 01.12.2000, p. 2-9.

Research output: Contribution to journalArticle

Kim, BS, Baez, CE & Atala, A 2000, 'Biomaterials for tissue engineering', World Journal of Urology, vol. 18, no. 1, pp. 2-9.
Kim BS, Baez CE, Atala A. Biomaterials for tissue engineering. World Journal of Urology. 2000 Dec 1;18(1):2-9.
Kim, Byung Soo ; Baez, Carlos E. ; Atala, Anthony. / Biomaterials for tissue engineering. In: World Journal of Urology. 2000 ; Vol. 18, No. 1. pp. 2-9.
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