Biomaterials for spinal cord repair

Agnes E. Haggerty, Martin Oudega

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Spinal cord injury (SCI) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi.

Original languageEnglish (US)
Pages (from-to)445-459
Number of pages15
JournalNeuroscience Bulletin
Volume29
Issue number4
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint

Spinal Cord Regeneration
Biocompatible Materials
Spinal Cord Injuries
Axons
Regeneration
Contusions
Social Problems
Wounds and Injuries
Growth
Polymers
Central Nervous System
Economics
Technology

Keywords

  • axon regeneration
  • biodegradable materials
  • extracellular matrix proteins
  • functional recovery
  • growth factor
  • guidance
  • injury and repair
  • spinal cord injury
  • spinal motor neuron

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Biomaterials for spinal cord repair. / Haggerty, Agnes E.; Oudega, Martin.

In: Neuroscience Bulletin, Vol. 29, No. 4, 08.2013, p. 445-459.

Research output: Contribution to journalArticle

Haggerty, Agnes E. ; Oudega, Martin. / Biomaterials for spinal cord repair. In: Neuroscience Bulletin. 2013 ; Vol. 29, No. 4. pp. 445-459.
@article{876354ffe1bf4ca889347898f96bde84,
title = "Biomaterials for spinal cord repair",
abstract = "Spinal cord injury (SCI) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi.",
keywords = "axon regeneration, biodegradable materials, extracellular matrix proteins, functional recovery, growth factor, guidance, injury and repair, spinal cord injury, spinal motor neuron",
author = "Haggerty, {Agnes E.} and Martin Oudega",
year = "2013",
month = "8",
doi = "10.1007/s12264-013-1362-7",
language = "English (US)",
volume = "29",
pages = "445--459",
journal = "Neuroscience Bulletin",
issn = "1673-7067",
publisher = "Science Press",
number = "4",

}

TY - JOUR

T1 - Biomaterials for spinal cord repair

AU - Haggerty, Agnes E.

AU - Oudega, Martin

PY - 2013/8

Y1 - 2013/8

N2 - Spinal cord injury (SCI) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi.

AB - Spinal cord injury (SCI) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi.

KW - axon regeneration

KW - biodegradable materials

KW - extracellular matrix proteins

KW - functional recovery

KW - growth factor

KW - guidance

KW - injury and repair

KW - spinal cord injury

KW - spinal motor neuron

UR - http://www.scopus.com/inward/record.url?scp=84881132549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881132549&partnerID=8YFLogxK

U2 - 10.1007/s12264-013-1362-7

DO - 10.1007/s12264-013-1362-7

M3 - Article

C2 - 23864367

AN - SCOPUS:84881132549

VL - 29

SP - 445

EP - 459

JO - Neuroscience Bulletin

JF - Neuroscience Bulletin

SN - 1673-7067

IS - 4

ER -