Biomaterials and immunomodulation for spinal cord repair

Martin Oudega, Inés Maldonado-Lasunción

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An injury to the spinal cord causes immediate loss of nervous tissue and impairments in function. The natural occurring immune response is compulsory, but, in later stages of spinal cord injury, becomes deleterious as a pro-inflammatory environment chronically persists, i.e., it does not shift towards an anti-inflammatory and pro-regenerative environment. The continuation of the pro-inflammatory immune response contributes to further exacerbation of nervous tissue damage, thereby augmenting the obstacles for endogenous or therapy-mediated repair. Precisely timely modulation of the immune response in the damaged spinal cord can be a compelling therapeutic modality to limit damage and facilitate repair. We will highlight the critical phases in spinal cord injury with the associated immune response and then discuss biomaterials that can be used to elicit immunomodulation and, therefore, hold therapeutic potential, alone or as a component in combination strategies, for the damaged spinal cord.

Original languageEnglish (US)
Title of host publicationImmunomodulatory Biomaterials
Subtitle of host publicationRegulating the Immune Response with Biomaterials to Affect Clinical Outcome
PublisherElsevier
Pages119-138
Number of pages20
ISBN (Electronic)9780128214404
DOIs
StatePublished - Jan 1 2021
Externally publishedYes

Keywords

  • Inflammation
  • Injury
  • Macrophages
  • Materials
  • Nervous tissue
  • Recovery

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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