Abstract
Background: We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers. METHODS AND Results: We measured several biomarkers of vascular dysfunction: C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, and antiretroviral therapy were recorded. Mean age was 14.8 years (106 HIV-infected children) and 12.3 years (55 control children). Sex and body mass index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to be greater in the HIV group, yet leptin and P-selectin were similar. In multivariable analyses in the HIV-infected children alone, each 1 standard deviation increase in waist to hip ratio was associated with increases in sICAM (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with sVCAM, MCP-1, IL6, fibrinogen, and CRP. Conclusions: HIV-infected children have higher levels of biomarkers of vascular dysfunction than healthy children. Risk factors associated with these biomarkers include higher waist to hip ratios and HIV disease severity.
| Original language | English |
|---|---|
| Pages (from-to) | 182-188 |
| Number of pages | 7 |
| Journal | Journal of Acquired Immune Deficiency Syndromes |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1 2010 |
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Keywords
- Biomarkers
- Cardiovascular risk factors
- Children
- HIV/AIDS
- Vascular dysfunction
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)
Cite this
Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1. / Miller, Tracie L; Somarriba, Gabriel; Orav, E. John; Mendez, Armando J; Neri, Daniela; Schaefer, Natasha; Forster, Lourdes; Goldberg, Ronald B; Scott, Gwendolyn B; Lipshultz, Steven E.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 55, No. 2, 01.10.2010, p. 182-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1
AU - Miller, Tracie L
AU - Somarriba, Gabriel
AU - Orav, E. John
AU - Mendez, Armando J
AU - Neri, Daniela
AU - Schaefer, Natasha
AU - Forster, Lourdes
AU - Goldberg, Ronald B
AU - Scott, Gwendolyn B
AU - Lipshultz, Steven E
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Background: We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers. METHODS AND Results: We measured several biomarkers of vascular dysfunction: C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, and antiretroviral therapy were recorded. Mean age was 14.8 years (106 HIV-infected children) and 12.3 years (55 control children). Sex and body mass index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to be greater in the HIV group, yet leptin and P-selectin were similar. In multivariable analyses in the HIV-infected children alone, each 1 standard deviation increase in waist to hip ratio was associated with increases in sICAM (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with sVCAM, MCP-1, IL6, fibrinogen, and CRP. Conclusions: HIV-infected children have higher levels of biomarkers of vascular dysfunction than healthy children. Risk factors associated with these biomarkers include higher waist to hip ratios and HIV disease severity.
AB - Background: We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers. METHODS AND Results: We measured several biomarkers of vascular dysfunction: C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, and antiretroviral therapy were recorded. Mean age was 14.8 years (106 HIV-infected children) and 12.3 years (55 control children). Sex and body mass index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to be greater in the HIV group, yet leptin and P-selectin were similar. In multivariable analyses in the HIV-infected children alone, each 1 standard deviation increase in waist to hip ratio was associated with increases in sICAM (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with sVCAM, MCP-1, IL6, fibrinogen, and CRP. Conclusions: HIV-infected children have higher levels of biomarkers of vascular dysfunction than healthy children. Risk factors associated with these biomarkers include higher waist to hip ratios and HIV disease severity.
KW - Biomarkers
KW - Cardiovascular risk factors
KW - Children
KW - HIV/AIDS
KW - Vascular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=77957311960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957311960&partnerID=8YFLogxK
U2 - 10.1097/QAI.0b013e3181e222c9
DO - 10.1097/QAI.0b013e3181e222c9
M3 - Article
C2 - 20531209
AN - SCOPUS:77957311960
VL - 55
SP - 182
EP - 188
JO - Journal of acquired immune deficiency syndromes (1999)
JF - Journal of acquired immune deficiency syndromes (1999)
SN - 1525-4135
IS - 2
ER -