Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1

Tracie L. Miller, Gabriel Somarriba, E. John Orav, Armando J. Mendez, Daniela Neri, Natasha Schaefer, Lourdes Forster, Ronald Goldberg, Gwendolyn B. Scott, Steven E. Lipshultz

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Background: We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers. METHODS AND Results: We measured several biomarkers of vascular dysfunction: C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, and antiretroviral therapy were recorded. Mean age was 14.8 years (106 HIV-infected children) and 12.3 years (55 control children). Sex and body mass index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to be greater in the HIV group, yet leptin and P-selectin were similar. In multivariable analyses in the HIV-infected children alone, each 1 standard deviation increase in waist to hip ratio was associated with increases in sICAM (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with sVCAM, MCP-1, IL6, fibrinogen, and CRP. Conclusions: HIV-infected children have higher levels of biomarkers of vascular dysfunction than healthy children. Risk factors associated with these biomarkers include higher waist to hip ratios and HIV disease severity.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume55
Issue number2
DOIs
StatePublished - Oct 1 2010

Keywords

  • Biomarkers
  • Cardiovascular risk factors
  • Children
  • HIV/AIDS
  • Vascular dysfunction

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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