Biomarkers in sarcopenia

A multifactorial approach

Francesco Curcio, Gaetana Ferro, Claudia Basile, Ilaria Liguori, Paolo Parrella, Flora Pirozzi, David Della Morte, Gaetano Gargiulo, Gianluca Testa, Carlo Gabriele Tocchetti, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

The slow and continuous loss of muscle mass that progresses with aging is defined as “sarcopenia”. Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis of sarcopenia requires the presence of low muscle mass, along with either low grip strength or low physical performance. However, age-related changes in skeletal muscle can be largely attributed to the complex interactions among factors including alterations of the neuromuscular junction, endocrine system, growth factors, and muscle proteins turnover, behavior-related and disease-related factors. Accordingly, the identification of a single biomarker of sarcopenia is unreliable, due to its “multifactorial” pathogenesis with the involvement of a multitude of pathways. Thus, in order to characterize pathophysiological mechanisms and to make a correct assessment of elderly patient with sarcopenia, a panel of biomarkers of all pathways involved should be assessed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalExperimental Gerontology
Volume85
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Sarcopenia
Biomarkers
Muscle
Muscle Proteins
Public health
Medical problems
Intercellular Signaling Peptides and Proteins
Aging of materials
Muscles
Endocrine System
Neuromuscular Junction
Hand Strength
Skeletal Muscle
Public Health

Keywords

  • Biomarkers
  • Diagnosis
  • Elderly
  • Sarcopenia

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

Curcio, F., Ferro, G., Basile, C., Liguori, I., Parrella, P., Pirozzi, F., ... Abete, P. (2016). Biomarkers in sarcopenia: A multifactorial approach. Experimental Gerontology, 85, 1-8. https://doi.org/10.1016/j.exger.2016.09.007

Biomarkers in sarcopenia : A multifactorial approach. / Curcio, Francesco; Ferro, Gaetana; Basile, Claudia; Liguori, Ilaria; Parrella, Paolo; Pirozzi, Flora; Della Morte, David; Gargiulo, Gaetano; Testa, Gianluca; Tocchetti, Carlo Gabriele; Bonaduce, Domenico; Abete, Pasquale.

In: Experimental Gerontology, Vol. 85, 01.12.2016, p. 1-8.

Research output: Contribution to journalReview article

Curcio, F, Ferro, G, Basile, C, Liguori, I, Parrella, P, Pirozzi, F, Della Morte, D, Gargiulo, G, Testa, G, Tocchetti, CG, Bonaduce, D & Abete, P 2016, 'Biomarkers in sarcopenia: A multifactorial approach', Experimental Gerontology, vol. 85, pp. 1-8. https://doi.org/10.1016/j.exger.2016.09.007
Curcio F, Ferro G, Basile C, Liguori I, Parrella P, Pirozzi F et al. Biomarkers in sarcopenia: A multifactorial approach. Experimental Gerontology. 2016 Dec 1;85:1-8. https://doi.org/10.1016/j.exger.2016.09.007
Curcio, Francesco ; Ferro, Gaetana ; Basile, Claudia ; Liguori, Ilaria ; Parrella, Paolo ; Pirozzi, Flora ; Della Morte, David ; Gargiulo, Gaetano ; Testa, Gianluca ; Tocchetti, Carlo Gabriele ; Bonaduce, Domenico ; Abete, Pasquale. / Biomarkers in sarcopenia : A multifactorial approach. In: Experimental Gerontology. 2016 ; Vol. 85. pp. 1-8.
@article{b078a8dd1d164d8eb745112d1cd85658,
title = "Biomarkers in sarcopenia: A multifactorial approach",
abstract = "The slow and continuous loss of muscle mass that progresses with aging is defined as “sarcopenia”. Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis of sarcopenia requires the presence of low muscle mass, along with either low grip strength or low physical performance. However, age-related changes in skeletal muscle can be largely attributed to the complex interactions among factors including alterations of the neuromuscular junction, endocrine system, growth factors, and muscle proteins turnover, behavior-related and disease-related factors. Accordingly, the identification of a single biomarker of sarcopenia is unreliable, due to its “multifactorial” pathogenesis with the involvement of a multitude of pathways. Thus, in order to characterize pathophysiological mechanisms and to make a correct assessment of elderly patient with sarcopenia, a panel of biomarkers of all pathways involved should be assessed.",
keywords = "Biomarkers, Diagnosis, Elderly, Sarcopenia",
author = "Francesco Curcio and Gaetana Ferro and Claudia Basile and Ilaria Liguori and Paolo Parrella and Flora Pirozzi and {Della Morte}, David and Gaetano Gargiulo and Gianluca Testa and Tocchetti, {Carlo Gabriele} and Domenico Bonaduce and Pasquale Abete",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.exger.2016.09.007",
language = "English (US)",
volume = "85",
pages = "1--8",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Biomarkers in sarcopenia

T2 - A multifactorial approach

AU - Curcio, Francesco

AU - Ferro, Gaetana

AU - Basile, Claudia

AU - Liguori, Ilaria

AU - Parrella, Paolo

AU - Pirozzi, Flora

AU - Della Morte, David

AU - Gargiulo, Gaetano

AU - Testa, Gianluca

AU - Tocchetti, Carlo Gabriele

AU - Bonaduce, Domenico

AU - Abete, Pasquale

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The slow and continuous loss of muscle mass that progresses with aging is defined as “sarcopenia”. Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis of sarcopenia requires the presence of low muscle mass, along with either low grip strength or low physical performance. However, age-related changes in skeletal muscle can be largely attributed to the complex interactions among factors including alterations of the neuromuscular junction, endocrine system, growth factors, and muscle proteins turnover, behavior-related and disease-related factors. Accordingly, the identification of a single biomarker of sarcopenia is unreliable, due to its “multifactorial” pathogenesis with the involvement of a multitude of pathways. Thus, in order to characterize pathophysiological mechanisms and to make a correct assessment of elderly patient with sarcopenia, a panel of biomarkers of all pathways involved should be assessed.

AB - The slow and continuous loss of muscle mass that progresses with aging is defined as “sarcopenia”. Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis of sarcopenia requires the presence of low muscle mass, along with either low grip strength or low physical performance. However, age-related changes in skeletal muscle can be largely attributed to the complex interactions among factors including alterations of the neuromuscular junction, endocrine system, growth factors, and muscle proteins turnover, behavior-related and disease-related factors. Accordingly, the identification of a single biomarker of sarcopenia is unreliable, due to its “multifactorial” pathogenesis with the involvement of a multitude of pathways. Thus, in order to characterize pathophysiological mechanisms and to make a correct assessment of elderly patient with sarcopenia, a panel of biomarkers of all pathways involved should be assessed.

KW - Biomarkers

KW - Diagnosis

KW - Elderly

KW - Sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=84988472780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988472780&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2016.09.007

DO - 10.1016/j.exger.2016.09.007

M3 - Review article

VL - 85

SP - 1

EP - 8

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -