Biomarkers in pediatric heart failure: Their role in diagnosis and evaluating disease progression

Paul F. Kantor, Paolo Rusconi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Biomarkers have established an important role in the diagnosis and prognosis of heart failure in adults. Several biomarkers of different classes have also demonstrated a practical or potential role in managing patients with heart failure. In the pediatric population, objective assessment of severity and disease progression is apt to be more difficult. Therefore, biomarkers may represent an objective tool to confirm functional status and echocardiographic indices of left ventricular dysfunction in children with heart failure. Since early detection of remodeling is vital to preemptive management, biomarkers may also serve to gauge the severity of the ventricular remodeling process in several different diseases. Thus far, B-type natriuretic peptide levels have been found to be associated with the severity and outcome of heart failure in children, correlating with symptom severity, functional status and degree of left ventricular remodeling. They have been found to predict cardiovascular events, and may guide medical treatment decisions in symptomatic heart failure. High-sensitivity C reactive protein, cytokines, cytokine receptors, cardiac troponins and gene expression profiling are all emerging as a useful assessment tools in adults with heart failure. Further study is required to validate the role of these measures in children with cardiomyopathies and with heart failure.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalProgress in Pediatric Cardiology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Disease Progression
Heart Failure
Biomarkers
Pediatrics
Ventricular Remodeling
Cytokine Receptors
Troponin
Brain Natriuretic Peptide
Left Ventricular Dysfunction
Gene Expression Profiling
Cardiomyopathies
C-Reactive Protein
Cytokines
Population

Keywords

  • Biological markers
  • Congestive heart failure
  • Natriuretic peptides
  • Pediatric
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Biomarkers in pediatric heart failure : Their role in diagnosis and evaluating disease progression. / Kantor, Paul F.; Rusconi, Paolo.

In: Progress in Pediatric Cardiology, Vol. 31, No. 1, 01.01.2011, p. 53-57.

Research output: Contribution to journalArticle

@article{cc9860f9e6e443199ed8eb9dca251248,
title = "Biomarkers in pediatric heart failure: Their role in diagnosis and evaluating disease progression",
abstract = "Biomarkers have established an important role in the diagnosis and prognosis of heart failure in adults. Several biomarkers of different classes have also demonstrated a practical or potential role in managing patients with heart failure. In the pediatric population, objective assessment of severity and disease progression is apt to be more difficult. Therefore, biomarkers may represent an objective tool to confirm functional status and echocardiographic indices of left ventricular dysfunction in children with heart failure. Since early detection of remodeling is vital to preemptive management, biomarkers may also serve to gauge the severity of the ventricular remodeling process in several different diseases. Thus far, B-type natriuretic peptide levels have been found to be associated with the severity and outcome of heart failure in children, correlating with symptom severity, functional status and degree of left ventricular remodeling. They have been found to predict cardiovascular events, and may guide medical treatment decisions in symptomatic heart failure. High-sensitivity C reactive protein, cytokines, cytokine receptors, cardiac troponins and gene expression profiling are all emerging as a useful assessment tools in adults with heart failure. Further study is required to validate the role of these measures in children with cardiomyopathies and with heart failure.",
keywords = "Biological markers, Congestive heart failure, Natriuretic peptides, Pediatric, Ventricular remodeling",
author = "Kantor, {Paul F.} and Paolo Rusconi",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.ppedcard.2010.11.012",
language = "English",
volume = "31",
pages = "53--57",
journal = "Progress in Pediatric Cardiology",
issn = "1058-9813",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Biomarkers in pediatric heart failure

T2 - Their role in diagnosis and evaluating disease progression

AU - Kantor, Paul F.

AU - Rusconi, Paolo

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Biomarkers have established an important role in the diagnosis and prognosis of heart failure in adults. Several biomarkers of different classes have also demonstrated a practical or potential role in managing patients with heart failure. In the pediatric population, objective assessment of severity and disease progression is apt to be more difficult. Therefore, biomarkers may represent an objective tool to confirm functional status and echocardiographic indices of left ventricular dysfunction in children with heart failure. Since early detection of remodeling is vital to preemptive management, biomarkers may also serve to gauge the severity of the ventricular remodeling process in several different diseases. Thus far, B-type natriuretic peptide levels have been found to be associated with the severity and outcome of heart failure in children, correlating with symptom severity, functional status and degree of left ventricular remodeling. They have been found to predict cardiovascular events, and may guide medical treatment decisions in symptomatic heart failure. High-sensitivity C reactive protein, cytokines, cytokine receptors, cardiac troponins and gene expression profiling are all emerging as a useful assessment tools in adults with heart failure. Further study is required to validate the role of these measures in children with cardiomyopathies and with heart failure.

AB - Biomarkers have established an important role in the diagnosis and prognosis of heart failure in adults. Several biomarkers of different classes have also demonstrated a practical or potential role in managing patients with heart failure. In the pediatric population, objective assessment of severity and disease progression is apt to be more difficult. Therefore, biomarkers may represent an objective tool to confirm functional status and echocardiographic indices of left ventricular dysfunction in children with heart failure. Since early detection of remodeling is vital to preemptive management, biomarkers may also serve to gauge the severity of the ventricular remodeling process in several different diseases. Thus far, B-type natriuretic peptide levels have been found to be associated with the severity and outcome of heart failure in children, correlating with symptom severity, functional status and degree of left ventricular remodeling. They have been found to predict cardiovascular events, and may guide medical treatment decisions in symptomatic heart failure. High-sensitivity C reactive protein, cytokines, cytokine receptors, cardiac troponins and gene expression profiling are all emerging as a useful assessment tools in adults with heart failure. Further study is required to validate the role of these measures in children with cardiomyopathies and with heart failure.

KW - Biological markers

KW - Congestive heart failure

KW - Natriuretic peptides

KW - Pediatric

KW - Ventricular remodeling

UR - http://www.scopus.com/inward/record.url?scp=79451471535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79451471535&partnerID=8YFLogxK

U2 - 10.1016/j.ppedcard.2010.11.012

DO - 10.1016/j.ppedcard.2010.11.012

M3 - Article

AN - SCOPUS:79451471535

VL - 31

SP - 53

EP - 57

JO - Progress in Pediatric Cardiology

JF - Progress in Pediatric Cardiology

SN - 1058-9813

IS - 1

ER -