Biomarkers associated with prostate cancer progression.

H. E. Zhau, L. L. Pisters, M. C. Hall, L. S. Zhao, P. Troncoso, Alan Pollack, L. W. Chung

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In search of biomarkers that predict of human prostate cancer progression, we hypothesized that these markers must be expressed in prostatic epithelial cells during multi-step prostate carcinogenesis. Since both genetic and epigenetic factors have been implicated in human prostate cancer development, two osseous-metastatic experimental models were developed in our laboratory, one based on gene transfection and the other on stromal-epithelial interaction studies. In the genetic model, PC-3 cells transfected with point-mutated c-erbB-2/neu oncogene subsequently acquired the potential to metastasize from the prostate to soft tissues and the skeleton. In the epigenetic model, sublines derived from the parental androgen-dependent LNCaP cell line metastasized from the primary tumor to the lymph node and bone. Cells with known lineage relationships were cloned from both the primary and the metastatic tumors and were characterized extensively using cellular, biochemical, immunohistochemical, and molecular techniques. Relevant stage-specific biomarkers associated with prostate cancer progression in these two models were defined and used to evaluate human prostate tissues obtained from the clinic. In this communication, we focused our discussion on the potential importance of c-erbB-2/neu oncogene, vimentin, hepatocyte growth factor/scatter factor and its receptor, c-met oncogene, tumor angiogenesis and neuroendocrine factors as biomarkers for human prostate cancer progression.

Original languageEnglish
Pages (from-to)208-216
Number of pages9
JournalJournal of cellular biochemistry. Supplement
Volume19
StatePublished - Dec 1 1994
Externally publishedYes

Fingerprint

Biomarkers
Prostatic Neoplasms
Oncogenes
Tumors
Prostate
Epigenomics
Proto-Oncogene Proteins c-met
Tissue
Hepatocyte Growth Factor
Neuroendocrine Tumors
Angiogenesis Inducing Agents
Genetic Models
Vimentin
Skeleton
Androgens
Transfection
Neoplasms
Bone
Carcinogenesis
Theoretical Models

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry
  • Cell Biology

Cite this

Zhau, H. E., Pisters, L. L., Hall, M. C., Zhao, L. S., Troncoso, P., Pollack, A., & Chung, L. W. (1994). Biomarkers associated with prostate cancer progression. Journal of cellular biochemistry. Supplement, 19, 208-216.

Biomarkers associated with prostate cancer progression. / Zhau, H. E.; Pisters, L. L.; Hall, M. C.; Zhao, L. S.; Troncoso, P.; Pollack, Alan; Chung, L. W.

In: Journal of cellular biochemistry. Supplement, Vol. 19, 01.12.1994, p. 208-216.

Research output: Contribution to journalArticle

Zhau, HE, Pisters, LL, Hall, MC, Zhao, LS, Troncoso, P, Pollack, A & Chung, LW 1994, 'Biomarkers associated with prostate cancer progression.', Journal of cellular biochemistry. Supplement, vol. 19, pp. 208-216.
Zhau HE, Pisters LL, Hall MC, Zhao LS, Troncoso P, Pollack A et al. Biomarkers associated with prostate cancer progression. Journal of cellular biochemistry. Supplement. 1994 Dec 1;19:208-216.
Zhau, H. E. ; Pisters, L. L. ; Hall, M. C. ; Zhao, L. S. ; Troncoso, P. ; Pollack, Alan ; Chung, L. W. / Biomarkers associated with prostate cancer progression. In: Journal of cellular biochemistry. Supplement. 1994 ; Vol. 19. pp. 208-216.
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