Bioluminescent stem-loop probes for highly sensitive nucleic acid detection

Eric A. Hunt, Sapna K. Deo

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Here, we report the first bioluminescent stem-loop probe, which is 50 times more sensitive and able to achieve a LOD 25 times lower than fluorescent stem-loop probes. Chemical generation of a signal from Renilla luciferase reduces background noise for improved quantitative utility in nucleic acid biomarker detection.

Original languageEnglish (US)
Pages (from-to)9393-9395
Number of pages3
JournalChemical Communications
Volume47
Issue number33
DOIs
StatePublished - Sep 7 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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