Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27

Alejandro V. Villarino, Christopher A. Hunter

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

IL-27 is a recently identified heterodimeric cytokine produced in response to microbial and host derived inflammatory cues. Initial studies indicated that IL-27 promotes the generation of Th1 responses required for resistance to intracellular infection and unveiled the molecular mechanisms mediating this effect. However, subsequent work uncovered a role for IL-27 in the suppression of Th1 and Th2 responses. Thus, by discussing its pleotropic functions in the context of infection-induced immunity and by drawing parallels to fellow IL-6/IL-12 family cytokines, this review will attempt to reconcile the pro- and anti-inflammatory effects of IL-27.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalArthritis Research and Therapy
Volume6
Issue number5
DOIs
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • IL-27
  • Infection
  • Th1
  • Th2
  • WSX-1

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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