Biological pathways to bladder carcinogenesis

M. L. Gonzalgo, M. P. Schoenberg, R. Rodriguez

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The transformation of normal urothelium into histologically different neoplastic states has been well characterized, and current clinical management of both superficial and invasive bladder cancer has benefited from recent scientific discoveries. The ability to define novel treatment strategies including surgical, chemotherapeutic, and gene therapies relies on our understanding of the basic mechanisms underlying human bladder carcinogenesis. Many in vitro culture systems and in vivo animal models have been developed over recent years, which have been used to define key molecular events that are associated with the development of bladder cancer. The biological pathways through which normal urothelium may progress to superficial or invasive disease will be discussed in the framework of recent advances in the field. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalSeminars in Urologic Oncology
Volume18
Issue number4
StatePublished - Dec 7 2000
Externally publishedYes

Keywords

  • Adenovirus
  • BCG
  • Bladder cancer
  • CAR
  • Gene therapy
  • Urology

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Gonzalgo, M. L., Schoenberg, M. P., & Rodriguez, R. (2000). Biological pathways to bladder carcinogenesis. Seminars in Urologic Oncology, 18(4), 256-263.