Biologic functions of blood group antigens

Raja Mudad, Marilyn J. Telen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In the past few years, we have learned a great deal about the biologic function of structures bearing blood group antigens. Some blood group antigen-bearing proteins function as major transport channels within the erythrocyte membrane; these include the anion transporter (band 3: Diego and Wright antigens), the water channel (aquaporin: Colton antigens), and the urea transporter (Kidd antigens). At least two erythrocyte blood group antigen proteins have complement regulatory functions: the complement receptor type 1 (CR1, CD35: Knops antigens) and decay accelerating factor (DAF, CD55: Cromer antigens). Some blood group antigens reside on proteins with known receptor functions, such as the chemokine receptor (Duffy) and the hyaluronan receptor (Indian). The Cartwright antigens reside on an enzyme, acetylcholinesterase, and the Kell antigens reside on a protein that belongs to the CALLA-related family of neutral metalloproteinases. Finally, some blood group antigens reside on proteins that serve crucial structural functions necessary to normal erythrocyte lifespan and morphology. These proteins include band 3, glycophorins C/D (bearing the Gerbich antigens), and the Rh proteins. Both oligosaccharide and protein blood group antigens may act as receptors for bacterial, viral, and parasitic infectious agents.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalCurrent Opinion in Hematology
Volume3
Issue number6
StatePublished - 1996
Externally publishedYes

Fingerprint

Blood Group Antigens
Antigens
CD55 Antigens
Aquaporins
Proteins
Erythrocytes
Complement 3b Receptors
CD44 Antigens
Erythrocyte Anion Exchange Protein 1
Glycophorin
Complement Receptors
Chemokine Receptors
Erythrocyte Membrane
Metalloproteases
Acetylcholinesterase
Oligosaccharides
Anions
Complement System Proteins
Enzymes

ASJC Scopus subject areas

  • Hematology

Cite this

Biologic functions of blood group antigens. / Mudad, Raja; Telen, Marilyn J.

In: Current Opinion in Hematology, Vol. 3, No. 6, 1996, p. 473-479.

Research output: Contribution to journalArticle

Mudad, Raja ; Telen, Marilyn J. / Biologic functions of blood group antigens. In: Current Opinion in Hematology. 1996 ; Vol. 3, No. 6. pp. 473-479.
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