Biogenesis, assembly and trafficking of acetylcholinesterase

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Acetylcholinesterase (AChE) is expressed as several homomeric and heterooligomeric forms in a wide variety of tissues such as neurons in the central and peripheral nervous systems and their targets including skeletal muscle, endocrine and exocrine glands. In addition, glycolipid-anchored forms are expressed in erythropoietic and lymphopoietic cells. While transcriptional and post-transcriptional regulation is important for determining which AChE oligomeric forms are expressed in a given tissue, translational and post-translational regulatory mechanisms at the level of protein folding, assembly and sorting play equally important roles in assuring that the AChE molecules reach their intended sites on the cell surface in the appropriate numbers. This brief review will focus on the latter events in the cell with the goal of providing novel therapeutic interventional strategies for the treatment of organophosphate and carbamate pesticide and nerve agent exposure. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.

Original languageEnglish (US)
JournalJournal of Neurochemistry
DOIs
StateAccepted/In press - 2017

Fingerprint

Acetylcholinesterase
Exocrine Glands
Tissue
Endocrine Glands
Protein folding
Carbamates
Organophosphates
Glycolipids
Protein Folding
Peripheral Nervous System
Neurology
Protein Transport
Sorting
Pesticides
Cholinergic Agents
Neurons
Muscle
Skeletal Muscle
Central Nervous System
Molecules

Keywords

  • Acetylcholine esterase
  • Cholinergic mechanisms
  • PRAD-KDEL peptides
  • XVth International Symposium on Cholinergic Mechanisms

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

@article{3f19876ded4c4091865464dc9fdff0c8,
title = "Biogenesis, assembly and trafficking of acetylcholinesterase",
abstract = "Acetylcholinesterase (AChE) is expressed as several homomeric and heterooligomeric forms in a wide variety of tissues such as neurons in the central and peripheral nervous systems and their targets including skeletal muscle, endocrine and exocrine glands. In addition, glycolipid-anchored forms are expressed in erythropoietic and lymphopoietic cells. While transcriptional and post-transcriptional regulation is important for determining which AChE oligomeric forms are expressed in a given tissue, translational and post-translational regulatory mechanisms at the level of protein folding, assembly and sorting play equally important roles in assuring that the AChE molecules reach their intended sites on the cell surface in the appropriate numbers. This brief review will focus on the latter events in the cell with the goal of providing novel therapeutic interventional strategies for the treatment of organophosphate and carbamate pesticide and nerve agent exposure. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.",
keywords = "Acetylcholine esterase, Cholinergic mechanisms, PRAD-KDEL peptides, XVth International Symposium on Cholinergic Mechanisms",
author = "Rotundo, {Richard L}",
year = "2017",
doi = "10.1111/jnc.13982",
language = "English (US)",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Biogenesis, assembly and trafficking of acetylcholinesterase

AU - Rotundo, Richard L

PY - 2017

Y1 - 2017

N2 - Acetylcholinesterase (AChE) is expressed as several homomeric and heterooligomeric forms in a wide variety of tissues such as neurons in the central and peripheral nervous systems and their targets including skeletal muscle, endocrine and exocrine glands. In addition, glycolipid-anchored forms are expressed in erythropoietic and lymphopoietic cells. While transcriptional and post-transcriptional regulation is important for determining which AChE oligomeric forms are expressed in a given tissue, translational and post-translational regulatory mechanisms at the level of protein folding, assembly and sorting play equally important roles in assuring that the AChE molecules reach their intended sites on the cell surface in the appropriate numbers. This brief review will focus on the latter events in the cell with the goal of providing novel therapeutic interventional strategies for the treatment of organophosphate and carbamate pesticide and nerve agent exposure. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.

AB - Acetylcholinesterase (AChE) is expressed as several homomeric and heterooligomeric forms in a wide variety of tissues such as neurons in the central and peripheral nervous systems and their targets including skeletal muscle, endocrine and exocrine glands. In addition, glycolipid-anchored forms are expressed in erythropoietic and lymphopoietic cells. While transcriptional and post-transcriptional regulation is important for determining which AChE oligomeric forms are expressed in a given tissue, translational and post-translational regulatory mechanisms at the level of protein folding, assembly and sorting play equally important roles in assuring that the AChE molecules reach their intended sites on the cell surface in the appropriate numbers. This brief review will focus on the latter events in the cell with the goal of providing novel therapeutic interventional strategies for the treatment of organophosphate and carbamate pesticide and nerve agent exposure. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.

KW - Acetylcholine esterase

KW - Cholinergic mechanisms

KW - PRAD-KDEL peptides

KW - XVth International Symposium on Cholinergic Mechanisms

UR - http://www.scopus.com/inward/record.url?scp=85016392016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016392016&partnerID=8YFLogxK

U2 - 10.1111/jnc.13982

DO - 10.1111/jnc.13982

M3 - Article

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

ER -