Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

Amarpreet S. Sawhney, Chandrashekhar P. Pathak, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

843 Scopus citations

Abstract

Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalMacromolecules
Volume26
Issue number4
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers'. Together they form a unique fingerprint.

  • Cite this