Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

Amarpreet S. Sawhney; Chandrashekhar P. Pathak; Jeffrey A. Hubbell

doi:10.1021/ma00056a005

Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

Amarpreet S. Sawhney, Chandrashekhar P. Pathak, Jeffrey A. Hubbell

Surgery

Research output: Contribution to journal › Article › peer-review

857 Scopus citations

Abstract

Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.

Original language	English (US)
Pages (from-to)	581-587
Number of pages	7
Journal	Macromolecules
Volume	26
Issue number	4
DOIs	https://doi.org/10.1021/ma00056a005
State	Published - Jan 1 1993

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1021/ma00056a005

Fingerprint Dive into the research topics of 'Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers'. Together they form a unique fingerprint.

Cite this

@article{c0b81df0e7674e0faf79f61ca470f7cb,

title = "Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers",

abstract = "Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.",

author = "Sawhney, {Amarpreet S.} and Pathak, {Chandrashekhar P.} and Hubbell, {Jeffrey A.}",

year = "1993",

month = jan,

day = "1",

doi = "10.1021/ma00056a005",

language = "English (US)",

volume = "26",

pages = "581--587",

journal = "Macromolecules",

issn = "0024-9297",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

AU - Sawhney, Amarpreet S.

AU - Pathak, Chandrashekhar P.

AU - Hubbell, Jeffrey A.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.

AB - Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.

UR - http://www.scopus.com/inward/record.url?scp=0027544568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027544568&partnerID=8YFLogxK

U2 - 10.1021/ma00056a005

DO - 10.1021/ma00056a005

M3 - Article

AN - SCOPUS:0027544568

VL - 26

SP - 581

EP - 587

JO - Macromolecules

JF - Macromolecules

SN - 0024-9297

IS - 4

ER -