Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

Amarpreet S. Sawhney; Chandrashekhar P. Pathak; Jeffrey A. Hubbell

doi:10.1021/ma00056a005

Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

Amarpreet S. Sawhney, Chandrashekhar P. Pathak, Jeffrey A. Hubbell

Surgery

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Abstract

Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.

Original language	English (US)
Pages (from-to)	581-587
Number of pages	7
Journal	Macromolecules
Volume	26
Issue number	4
DOIs	https://doi.org/10.1021/ma00056a005
State	Published - Jan 1 1993

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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AU - Hubbell, Jeffrey A.

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AB - Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.

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Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers

Abstract

ASJC Scopus subject areas

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