Abstract
Macromers having a poly(ethylene glycol) central block, extended with oligomers of α-hydroxy acids such as oligo(dl-lactic acid) or oligo(glycolic acid) and terminated with acrylate groups, were synthesized and characterized with the goal of obtaining a bioerodible hydrogel that could be formed in direct contact with tissues or proteins by photopolymerization of aqueous solutions of the macromer. It was determined that the PEG component of these macromers must be greater than approximately 55 mol% to provide water solubility. These novel materials are suitable for a number of biomedical applications and show potential for use in macromolecular drug delivery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 581-587 |
| Number of pages | 7 |
| Journal | Macromolecules |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1993 |
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Inorganic Chemistry
- Materials Chemistry
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Cite this
Sawhney, A. S., Pathak, C. P., & Hubbell, J. A. (1993). Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly (α-hydroxy acid) Diacrylate Macromers. Macromolecules, 26(4), 581-587. https://doi.org/10.1021/ma00056a005