Bioengineering of the Lower Urinary Tract

Majid Mirzazadeh, Anthony Atala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The goal of urinary tissue engineering is to develop biologic substitutes that can restore and maintain normal function.Investigators have attempted alternative reconstructive procedures for bladder replacement or repair such as the use of tissue expansion, matrices for tissue regeneration, and tissue engineering with cell transplantation.A critical aspect of regenerating a large portion of bladder tissue is the bioscaffold selection, which could be natural or synthetic polymers. Since cells cannot be implanted in volumes exceeding 3 cubic millimeters, because of the limitations of nutrition and gas exchange, vascularization of the regenerating cells is essential. Culturing the harvested cells from the organ of interest and different types of stem cells are potential sources of cells in tissue regeneration.Ureter and urethra have been other targets for tissue regeneration. Ureteral nonseeded matrices have been used as a scaffold for the ingrowth of ureteral tissue in rats. Also, synthetic biomaterials, tabularized and seeded with autologous cells have been used in urethral reconstruction.Recent progresses suggest that engineered urologic tissues and cell therapy has great potential but challenges remain.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages737-745
Number of pages9
ISBN (Print)9780123985231
DOIs
StatePublished - Jan 1 2014

Keywords

  • Bioengineering
  • Biomaterial
  • Bladder
  • Regeneration
  • Scaffold
  • Stem cell
  • Tissue engineering
  • Ureter
  • Urethra

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Mirzazadeh, M., & Atala, A. (2014). Bioengineering of the Lower Urinary Tract. In Regenerative Medicine Applications in Organ Transplantation (pp. 737-745). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00052-5