Bioengineered corporal tissue for structural and functional restoration of the penis

Kuo Liang Chen, Daniel Eberli, James J. Yoo, Anthony Atala

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that a short segment of the penile corporal body can be replaced using naturally derived collagenmatrices with autologous cells. In the current study, we examined the feasibility of engineeringthe entire pendularpenile corporal bodies in a rabbit model. Neocorporawere engineered from cavernosal collagen matrices seeded with autologous cells using a multistep static/dynamic procedure, and these were implanted to replace the excised corpora. The bioengineered corpora demonstrated structural and functional parameters similar to native tissue and male rabbits receiving the bilateral implants were able to successfully impregnate females. This study demonstrates that neocorpora can be engineered for total pendular penile corporal body replacement. This technology has considerable potential for patients requiring penile reconstruction.

Original languageEnglish
Pages (from-to)3346-3350
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number8
DOIs
StatePublished - Feb 23 2010
Externally publishedYes

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Keywords

  • Autologous transplantation
  • Bioengineered corpora
  • Erectile dysfunction
  • Penile reconstruction

ASJC Scopus subject areas

  • General

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