Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors

A. M. Markoe, V. R. Risch, N. D. Heindel, J. Emrich, W. Lippincott, T. Honda, L. W. Brady

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

5-thio-D-glucose (5-TDG) exerts profound effects on rapidly metabolizing tissues. The authors have used liquid scintillation counting to study the tissue distribution and pharmacokinetics of S-35-labeled 5-TDG in hamster models of pancreatic tumors. In the normal hamster, initial uptake of S-35 activity into kidney, liver, and blood was high, but rapidly decreased with time. The pancreatic uptake (% dose/g) never exceeded 0.75%. This level occurred only at the earliest times after administration. Uptake in all 3 tumor models exceeded that in pancreatic tissue within 15 min of injection. The highest tumor-to-pancreas ratio was seen in the duct-tumor model, which also exhibited the most favorable tumor-to-tissue ratio when compared with kidney, liver, and muscle. Favorable ratios were most pronounced at 6 and 24 hr after injection. These studies provide impetus for the use of 5-TDG as a model compound for the synthesis of potentially useful agents for clinical detection of pancreatic tumors.

Original languageEnglish (US)
Pages (from-to)753-760
Number of pages8
JournalJournal of Nuclear Medicine
Volume20
Issue number7
StatePublished - Nov 15 1979
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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