Biodistribution and clearance of magnetoelectric nanoparticles for nanomedical applications using energy dispersive spectroscopy

Ali Hadjikhani, Alexa Rodzinski, Ping Wang, Abhignyan Nagesetti, Rakesh Guduru, Ping Liang, Carolyn Runowicz, Sina Shahbazmohamadi, Sakhrat Khizroev

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Aim: The biodistribution and clearance of magnetoelectric nanoparticles (MENs) in a mouse model was studied through electron energy dispersive spectroscopy. Materials & methods: This approach allows for detection of nanoparticles (NPs) in tissues with the spatial resolution of scanning electron microscopy, does not require any tissue-sensitive staining and is not limited to MENs. Results: The size-dependent biodistribution of intravenously administrated MENs was measured in vital organs such as the kidneys, liver, spleen, lungs and brain at four different postinjection times including 1 day, 1 week, 4 and 8 weeks, respectively. Conclusion: The smallest NPs, 10-nm MENs, were cleared relatively rapidly and uniformly across the organs, while the clearance of the larger NPs, 100- and 600-nm MENs, was highly nonlinear with time and nonuniform across the organs.

Original languageEnglish (US)
Pages (from-to)1801-1822
Number of pages22
JournalNanomedicine
Volume12
Issue number15
DOIs
StatePublished - Aug 2017

Keywords

  • biodistribution
  • clearance
  • magnetoelectric nanoparticles
  • multiferroic nanoparticles
  • nanomedicine

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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