Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases

Antonio C. Bianco, Domenico Salvatore, Balázs Gereben, Marla J. Berry, P. Reed Larsen

Research output: Contribution to journalReview article

1256 Scopus citations

Abstract

The goal of this review is to place the exciting advances that have occurred in our understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical and physiological context. We review new data regarding the mechanism of selenoprotein synthesis, the molecular and cellular biological properties of the individual deiodinases, including gene structure, mRNA and protein characteristics, tissue distribution, subcellular localization and topology, enzymatic properties, structure-activity relationships, and regulation of synthesis, inactivation, and degradation. These provide the background for a discussion of their role in thyroid physiology in humans and other vertebrates, including evidence that D2 plays a significant role in human plasma T3 production. We discuss the pathological role of D3 overexpression causing "consumptive hypothyroidism" as well as our current understanding of the pathophysiology of iodothyronine deiodination during illness and amiodarone therapy. Finally, we review the new insights from analysis of mice with targeted disruption of the Dio2 gene and overexpression of D2 in the myocardium.

Original languageEnglish (US)
Pages (from-to)38-89
Number of pages52
JournalEndocrine Reviews
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases'. Together they form a unique fingerprint.

  • Cite this