Biochemical effects of phosphatidylcholine treatment in rats

Richard S Jope, Donald J. Jenden, Carole S. Subramanian, Govind A. Dhopeshwarker, John Duncan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We measured several biochemical effects of 10 days of intragastric administration of phosphatidylcholine (10 mmoles/kg) to rats because of the expanding clinical use of chronic phosphatidylcholine treatment for disorders involving impaired cholinergic neurotransmission. The plasma and erythrocyte choline concentrations were increased 3.5-fold, which was the same percent increase as found after an acute treatment with phosphatidylcholine. The lipid and fatty acid compositions of the plasma were also altered; free and total cholesterol levels increased, triglycerides increased, the monoene fatty acids generally decreased, and the diene and tetraene fatty acids generally increased. We found no effect of this treatment on the hepatic microsomal cytochrome P-450 activity or on the N-demethylation of benzphetamine or methamphetamine. Ten days of phosphatidylcholine treatment increased the concentration of choline in the brain but had no effect on the concentration of acetylcholine, the activity of choline acetyltransferase, cholinesterase activity, the apparent KD or Bmax of muscarinic receptors, or the fatty acid composition of rat brain lipids. These findings indicate that the largest effect caused by this treatment was an increase in the choline levels. No indication of altered cholinergic metabolism was observed. Further studies of the effects of chronic phosphatidylcholine treatment are required to clarify its therapeutic mechanism of action.

Original languageEnglish
Pages (from-to)793-798
Number of pages6
JournalBiochemical Pharmacology
Volume33
Issue number5
DOIs
StatePublished - Mar 1 1984
Externally publishedYes

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Phosphatidylcholines
Rats
Fatty Acids
Choline
Cholinergic Agents
Brain
Benzphetamine
Lipids
Plasmas
Choline O-Acetyltransferase
Methamphetamine
Cholinesterases
Muscarinic Receptors
Chemical analysis
Metabolism
Synaptic Transmission
Cytochrome P-450 Enzyme System
Acetylcholine
Triglycerides
Erythrocytes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Jope, R. S., Jenden, D. J., Subramanian, C. S., Dhopeshwarker, G. A., & Duncan, J. (1984). Biochemical effects of phosphatidylcholine treatment in rats. Biochemical Pharmacology, 33(5), 793-798. https://doi.org/10.1016/0006-2952(84)90464-7

Biochemical effects of phosphatidylcholine treatment in rats. / Jope, Richard S; Jenden, Donald J.; Subramanian, Carole S.; Dhopeshwarker, Govind A.; Duncan, John.

In: Biochemical Pharmacology, Vol. 33, No. 5, 01.03.1984, p. 793-798.

Research output: Contribution to journalArticle

Jope, RS, Jenden, DJ, Subramanian, CS, Dhopeshwarker, GA & Duncan, J 1984, 'Biochemical effects of phosphatidylcholine treatment in rats', Biochemical Pharmacology, vol. 33, no. 5, pp. 793-798. https://doi.org/10.1016/0006-2952(84)90464-7
Jope, Richard S ; Jenden, Donald J. ; Subramanian, Carole S. ; Dhopeshwarker, Govind A. ; Duncan, John. / Biochemical effects of phosphatidylcholine treatment in rats. In: Biochemical Pharmacology. 1984 ; Vol. 33, No. 5. pp. 793-798.
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