Biochemical changes in hepatic microsomes of Guinea-pig under lantana toxicity

O. P. Sharma, H. P.S. Makkar, Rajinder Dawra

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. Lantana intoxication of guinea-pig caused a decrease in hepatic microsomal protein content, the phospholipid: protein ratio, and the cholesterol: protein ratio. 2. Activities of aniline hydroxylase, aminopyrine N-demethylase, NADH-cytochrome c reductase, NADH-ferricyanide reductase, UDP-glucuronosyl transferase, cytochrome P-450 and glucose 6-phosphatase were decreased. 3. Activities of Mg2+-ATPase and Na+-K+-ATPase were increased. However, activities of 5-nucleotidase and NADPH-cytochrome c reductase were unaffected. 4. The liver endoplasmic reticulum is an important target organelle during lantana poisoning of guinea-pigs.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalXenobiotica
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Lantana
Microsomes
Toxicity
Guinea Pigs
Liver
Aminopyrine N-Demethylase
Aniline Hydroxylase
NADH Dehydrogenase
Ca(2+) Mg(2+)-ATPase
Glucose-6-Phosphatase
NADPH-Ferrihemoprotein Reductase
5'-Nucleotidase
Proteins
Uridine Diphosphate
Transferases
Endoplasmic Reticulum
Organelles
Poisoning
Cytochrome P-450 Enzyme System
Adenosine Triphosphatases

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

Cite this

Biochemical changes in hepatic microsomes of Guinea-pig under lantana toxicity. / Sharma, O. P.; Makkar, H. P.S.; Dawra, Rajinder.

In: Xenobiotica, Vol. 12, No. 4, 01.01.1982, p. 265-269.

Research output: Contribution to journalArticle

Sharma, O. P. ; Makkar, H. P.S. ; Dawra, Rajinder. / Biochemical changes in hepatic microsomes of Guinea-pig under lantana toxicity. In: Xenobiotica. 1982 ; Vol. 12, No. 4. pp. 265-269.
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