Biochemical changes in hepatic microsomes of Guinea-pig under lantana toxicity

O. P. Sharma, H. P.S. Makkar, R. K. Dawra

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

1. Lantana intoxication of guinea-pig caused a decrease in hepatic microsomal protein content, the phospholipid: protein ratio, and the cholesterol: protein ratio. 2. Activities of aniline hydroxylase, aminopyrine N-demethylase, NADH-cytochrome c reductase, NADH-ferricyanide reductase, UDP-glucuronosyl transferase, cytochrome P-450 and glucose 6-phosphatase were decreased. 3. Activities of Mg2+-ATPase and Na+-K+-ATPase were increased. However, activities of 5-nucleotidase and NADPH-cytochrome c reductase were unaffected. 4. The liver endoplasmic reticulum is an important target organelle during lantana poisoning of guinea-pigs.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalXenobiotica
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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