Biochemical and pathological predictors of the recurrence of prostatic adenocarcinoma with seminal vesicle invasion

Mario Sofer, Marc Savoie, Sandy S. Kim, Francisco Civantos, Mark S. Soloway

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Purpose: We assessed biochemical and pathological factors as predictors of recurrence in men with seminal vesicle invasion. Materials and Methods: A consecutive series of 812 men who underwent radical retropubic prostatectomy between 1992 and 2000 included 106 (13%) with seminal vesicle invasion. Disease recurrence was defined as prostate specific antigen (PSA) 0.4 ng./ml. or greater. Patients with less than 12 months of followup, salvage radical retropubic prostatectomy, lymph node metastases and adjuvant therapy were excluded from study. Data on the remaining 66 cases were analyzed using the chi-square test, bivariate logistic regression, Kaplan-Meier analyses and Cox proportional regression. Variables included demographics, recurrence, time from surgery to recurrence, positive margins, capsular invasion, extracapsular extension, Gleason score (2 to 6, 7 and 8 to 10), and dichotomized values of preoperative PSA (10 or less versus 10 ng./ml.) and tumor volume (20% or less versus greater than 20%). Results: Mean patient age was 62 years (range 48 to 74). At an average followup of 47.7 months (range 13 to 109) 53% of the patients were free of biochemical recurrence. Mean time to recurrence was 18.6 months (range 1.7 to 51.6). Univariate analyses revealed a statistical significant increased risk of recurrence in patients with PSA greater than 10 ng./ml. (p <0.0001), capsular invasion (p = 0.01) and age (p = 0.036). When adjusting for potential covariates, Cox proportional regression analysis indicated that higher PSA (hazard ratio 7.33, 95% CI 2.57 to 20.95), larger tumor volume (hazard ratio 5.64, 95% CI 1.97 to 16.19) and higher age (hazard ratio 1.13, 95% CI 1.04 to 1.22) were significantly associated with shorter time to recurrence. Conclusions: PSA greater than 10 ng./ml., tumor volume greater than 20% and age are significant predictors of recurrence after radical retropubic prostatectomy in patients with prostate cancer and seminal vesicle invasion. Hopefully future randomized trials may show a survival benefit of adjuvant therapy in patients at high risk.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalJournal of Urology
Volume169
Issue number1
StatePublished - Jan 1 2003

Fingerprint

Seminal Vesicles
Adenocarcinoma
Recurrence
Prostate-Specific Antigen
Prostatectomy
Tumor Burden
Neoplasm Grading
Kaplan-Meier Estimate
Chi-Square Distribution
Prostatic Neoplasms
Logistic Models
Lymph Nodes
Regression Analysis
Demography
Neoplasm Metastasis
Survival
Therapeutics

Keywords

  • Adenocarcinoma
  • Prostate
  • Prostatectomy
  • Prostatic neoplasms
  • Seminal vesicles

ASJC Scopus subject areas

  • Urology

Cite this

Biochemical and pathological predictors of the recurrence of prostatic adenocarcinoma with seminal vesicle invasion. / Sofer, Mario; Savoie, Marc; Kim, Sandy S.; Civantos, Francisco; Soloway, Mark S.

In: Journal of Urology, Vol. 169, No. 1, 01.01.2003, p. 153-156.

Research output: Contribution to journalArticle

Sofer, Mario ; Savoie, Marc ; Kim, Sandy S. ; Civantos, Francisco ; Soloway, Mark S. / Biochemical and pathological predictors of the recurrence of prostatic adenocarcinoma with seminal vesicle invasion. In: Journal of Urology. 2003 ; Vol. 169, No. 1. pp. 153-156.
@article{c539f20cef91406786e91dbee5001ff8,
title = "Biochemical and pathological predictors of the recurrence of prostatic adenocarcinoma with seminal vesicle invasion",
abstract = "Purpose: We assessed biochemical and pathological factors as predictors of recurrence in men with seminal vesicle invasion. Materials and Methods: A consecutive series of 812 men who underwent radical retropubic prostatectomy between 1992 and 2000 included 106 (13{\%}) with seminal vesicle invasion. Disease recurrence was defined as prostate specific antigen (PSA) 0.4 ng./ml. or greater. Patients with less than 12 months of followup, salvage radical retropubic prostatectomy, lymph node metastases and adjuvant therapy were excluded from study. Data on the remaining 66 cases were analyzed using the chi-square test, bivariate logistic regression, Kaplan-Meier analyses and Cox proportional regression. Variables included demographics, recurrence, time from surgery to recurrence, positive margins, capsular invasion, extracapsular extension, Gleason score (2 to 6, 7 and 8 to 10), and dichotomized values of preoperative PSA (10 or less versus 10 ng./ml.) and tumor volume (20{\%} or less versus greater than 20{\%}). Results: Mean patient age was 62 years (range 48 to 74). At an average followup of 47.7 months (range 13 to 109) 53{\%} of the patients were free of biochemical recurrence. Mean time to recurrence was 18.6 months (range 1.7 to 51.6). Univariate analyses revealed a statistical significant increased risk of recurrence in patients with PSA greater than 10 ng./ml. (p <0.0001), capsular invasion (p = 0.01) and age (p = 0.036). When adjusting for potential covariates, Cox proportional regression analysis indicated that higher PSA (hazard ratio 7.33, 95{\%} CI 2.57 to 20.95), larger tumor volume (hazard ratio 5.64, 95{\%} CI 1.97 to 16.19) and higher age (hazard ratio 1.13, 95{\%} CI 1.04 to 1.22) were significantly associated with shorter time to recurrence. Conclusions: PSA greater than 10 ng./ml., tumor volume greater than 20{\%} and age are significant predictors of recurrence after radical retropubic prostatectomy in patients with prostate cancer and seminal vesicle invasion. Hopefully future randomized trials may show a survival benefit of adjuvant therapy in patients at high risk.",
keywords = "Adenocarcinoma, Prostate, Prostatectomy, Prostatic neoplasms, Seminal vesicles",
author = "Mario Sofer and Marc Savoie and Kim, {Sandy S.} and Francisco Civantos and Soloway, {Mark S.}",
year = "2003",
month = "1",
day = "1",
language = "English",
volume = "169",
pages = "153--156",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Biochemical and pathological predictors of the recurrence of prostatic adenocarcinoma with seminal vesicle invasion

AU - Sofer, Mario

AU - Savoie, Marc

AU - Kim, Sandy S.

AU - Civantos, Francisco

AU - Soloway, Mark S.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Purpose: We assessed biochemical and pathological factors as predictors of recurrence in men with seminal vesicle invasion. Materials and Methods: A consecutive series of 812 men who underwent radical retropubic prostatectomy between 1992 and 2000 included 106 (13%) with seminal vesicle invasion. Disease recurrence was defined as prostate specific antigen (PSA) 0.4 ng./ml. or greater. Patients with less than 12 months of followup, salvage radical retropubic prostatectomy, lymph node metastases and adjuvant therapy were excluded from study. Data on the remaining 66 cases were analyzed using the chi-square test, bivariate logistic regression, Kaplan-Meier analyses and Cox proportional regression. Variables included demographics, recurrence, time from surgery to recurrence, positive margins, capsular invasion, extracapsular extension, Gleason score (2 to 6, 7 and 8 to 10), and dichotomized values of preoperative PSA (10 or less versus 10 ng./ml.) and tumor volume (20% or less versus greater than 20%). Results: Mean patient age was 62 years (range 48 to 74). At an average followup of 47.7 months (range 13 to 109) 53% of the patients were free of biochemical recurrence. Mean time to recurrence was 18.6 months (range 1.7 to 51.6). Univariate analyses revealed a statistical significant increased risk of recurrence in patients with PSA greater than 10 ng./ml. (p <0.0001), capsular invasion (p = 0.01) and age (p = 0.036). When adjusting for potential covariates, Cox proportional regression analysis indicated that higher PSA (hazard ratio 7.33, 95% CI 2.57 to 20.95), larger tumor volume (hazard ratio 5.64, 95% CI 1.97 to 16.19) and higher age (hazard ratio 1.13, 95% CI 1.04 to 1.22) were significantly associated with shorter time to recurrence. Conclusions: PSA greater than 10 ng./ml., tumor volume greater than 20% and age are significant predictors of recurrence after radical retropubic prostatectomy in patients with prostate cancer and seminal vesicle invasion. Hopefully future randomized trials may show a survival benefit of adjuvant therapy in patients at high risk.

AB - Purpose: We assessed biochemical and pathological factors as predictors of recurrence in men with seminal vesicle invasion. Materials and Methods: A consecutive series of 812 men who underwent radical retropubic prostatectomy between 1992 and 2000 included 106 (13%) with seminal vesicle invasion. Disease recurrence was defined as prostate specific antigen (PSA) 0.4 ng./ml. or greater. Patients with less than 12 months of followup, salvage radical retropubic prostatectomy, lymph node metastases and adjuvant therapy were excluded from study. Data on the remaining 66 cases were analyzed using the chi-square test, bivariate logistic regression, Kaplan-Meier analyses and Cox proportional regression. Variables included demographics, recurrence, time from surgery to recurrence, positive margins, capsular invasion, extracapsular extension, Gleason score (2 to 6, 7 and 8 to 10), and dichotomized values of preoperative PSA (10 or less versus 10 ng./ml.) and tumor volume (20% or less versus greater than 20%). Results: Mean patient age was 62 years (range 48 to 74). At an average followup of 47.7 months (range 13 to 109) 53% of the patients were free of biochemical recurrence. Mean time to recurrence was 18.6 months (range 1.7 to 51.6). Univariate analyses revealed a statistical significant increased risk of recurrence in patients with PSA greater than 10 ng./ml. (p <0.0001), capsular invasion (p = 0.01) and age (p = 0.036). When adjusting for potential covariates, Cox proportional regression analysis indicated that higher PSA (hazard ratio 7.33, 95% CI 2.57 to 20.95), larger tumor volume (hazard ratio 5.64, 95% CI 1.97 to 16.19) and higher age (hazard ratio 1.13, 95% CI 1.04 to 1.22) were significantly associated with shorter time to recurrence. Conclusions: PSA greater than 10 ng./ml., tumor volume greater than 20% and age are significant predictors of recurrence after radical retropubic prostatectomy in patients with prostate cancer and seminal vesicle invasion. Hopefully future randomized trials may show a survival benefit of adjuvant therapy in patients at high risk.

KW - Adenocarcinoma

KW - Prostate

KW - Prostatectomy

KW - Prostatic neoplasms

KW - Seminal vesicles

UR - http://www.scopus.com/inward/record.url?scp=0037213719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037213719&partnerID=8YFLogxK

M3 - Article

VL - 169

SP - 153

EP - 156

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -